Krelor 20mg (Rosuvastatin Calcium)

Adult dosage

It can be administered at any time during the day regardless of meals. The initial dosage is 5 milligrams once daily, while the maintenance dose is 10 milligrams once daily, which is adjusted in most patients. The maintenance dose should be appropriately adjusted according to LDL cholesterol levels, treatment goals, and patient response, with a maximum increase to 20 milligrams per day.

Children's dosage

For pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17), the usual dosage range is 5 milligrams to 20 milligrams once daily. The dosage should be adjusted at intervals of 4 weeks or more as recommended.

This medication should not be used in certain patients. For instance, patients with allergies to this drug's components, those with severe liver impairment, patients with muscle disorders, and those with significantly reduced kidney function should not take this drug. Women who are pregnant or nursing, or those of childbearing age who are not using appropriate contraceptive methods should avoid this drug. Additionally, patients vulnerable to muscle-related disorders should avoid high doses. This drug contains lactose, so patients with certain genetic conditions like lactose intolerance should not take it. Patients with a history of liver disease or excessive alcohol consumption should have regular liver function tests while taking this medication. Those with conditions such as hypothyroidism or nephrotic syndrome should have these conditions treated first. If symptoms of myalgia or muscle weakness occur, patients should immediately inform their doctor, and if necessary, blood tests should be conducted to check for muscle damage. Caution is advised when taking other medications as some may increase the risk of muscle problems. High doses may cause temporary changes in kidney function, thus kidney function tests should also be considered. Asian patients may have higher systemic exposure to this drug, requiring potential dosage adjustments. This drug may rarely cause serious skin reactions or liver damage; if symptoms such as rash or jaundice occur, the medication should be discontinued immediately, and medical consultation should be sought. During pregnancy or nursing, this drug can be harmful to the fetus or infant; thus, its use should be avoided, and women who could become pregnant should ensure they are utilizing appropriate contraceptive methods. There is no specific antidote for overdose; treatment is symptomatic, and liver function and muscle-related tests should be continuously monitored. Lastly, this drug is unlikely to affect driving or operating machinery but caution should be taken as dizziness may occur.

Serious side effects

Hives, hypersensitivity reactions including angioedema, pancreatitis, myopathy (including myositis), rhabdomyolysis, severe muscle weakness, ophthalmoplegia, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), jaundice, hepatitis, polyneuropathy, severe dermatological reactions, severe allergic reactions, difficulty breathing, asthma attacks, liver abnormalities (jaundice), severe neurological symptoms, severe injuries

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• myalgia
• weakness
• hematuria
• diarrhea

This medication should be stored in a tightly closed container to protect it from air and moisture. It is important to maintain the storage temperature between 1 to 30 degrees Celsius.

Appearance

Pink round film-coated tablet

Package unit

30 tablets (10 tablets/PTP × 3)