Roxerin Tablets (Loxoprofen Sodium Hydrate)

Adult dose

1. For indications 1 and 2: Adults: Administer loxoprofen sodium (anhydrous) 60 mg orally three times a day. For single-dose therapy: 60–120 mg may be administered orally. 2. For indication 3: Adults: Administer loxoprofen sodium (anhydrous) 60 mg orally. In principle, it can be administered twice a day, with a maximum daily dose of 180 mg. It is preferable to avoid taking it on an empty stomach.

This medication can cause gastrointestinal bleeding in individuals who regularly consume three or more alcoholic drinks per day, so it is essential to consult with a physician or pharmacist before use. It may increase the risk of cardiovascular disease, so individuals with heart conditions or risk factors should exercise extra caution and consult medical personnel immediately if cardiovascular symptoms appear. Serious gastrointestinal adverse reactions such as gastrointestinal bleeding, ulcers, and perforation may occur; therefore, elderly patients and those with a history of gastrointestinal diseases should closely monitor any gastrointestinal symptoms while taking this medication. Patients with peptic ulcers, severe blood disorders, liver or kidney impairment, congestive heart failure, pregnant women in late pregnancy, breastfeeding mothers, and those allergic to this medication or its ingredients should not take this medication. Individuals with a history of peptic ulcers or gastrointestinal ulcers from the use of non-steroidal anti-inflammatory drugs should take this medication with caution, and those with a history of blood disorders or liver or kidney disease should also use it carefully. If symptoms of hypersensitivity such as rash, urticaria, difficulty breathing, or hypotension occur, stop taking the medication immediately and seek medical attention. Gastrointestinal symptoms may include abdominal pain, nausea, vomiting, diarrhea, and constipation; if hematemesis, melena, or severe abdominal pain occurs, stop taking the medication immediately. This medication may cause neurological adverse reactions such as drowsiness, dizziness, and headache, so caution is required when driving or operating machinery. Symptoms like liver dysfunction, kidney impairment, blood disorders, and congestive heart failure may occur, requiring regular monitoring; stop taking the medication if any abnormal symptoms appear. This medication should not be taken with other non-steroidal anti-inflammatory drugs, and drug interactions may occur when combined with certain medications, so inform your healthcare provider of any concurrent medications. It should not be taken during pregnancy, especially in late pregnancy, as it may pose a risk to the fetus; women of childbearing age should consult a physician and use the minimum dosage for the shortest duration possible. Safety in children has not been established, so it is advisable not to use it in children. Elderly patients should be especially cautious as the risk of adverse reactions is higher with this medication. Store this medication out of the reach of children and do not transfer it to another container to ensure safety.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, shock, anaphylaxis-like symptoms, peptic ulcer, bleeding, perforation, hematemesis, melena, blood in stool, severe skin adverse reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, mucocutaneous syndrome), jaundice, acute renal failure, respiratory distress, asthma attacks, liver dysfunction (jaundice), fulminant hepatitis, aseptic meningitis, severe edema, hypertension, palpitations, myocardial infarction.

Mild side effects

• Occasionally
• rash
• itching
• fever
• abdominal pain
• discomfort in the upper abdomen
• loss of appetite
• nausea
• vomiting
• diarrhea

This medication should be stored in a tightly closed package to protect it from air and moisture. It is advisable to keep it at a temperature between 1 to 30 degrees Celsius.

Appearance

Round tablets, light pink

Package unit

30 tablets/bottle, 500 tablets/bottle