Hyperzium ODT 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. After administering the 5 mg dose for 4 to 6 weeks, evaluate clinical response to consider increasing to 10 mg. When increasing to 10 mg per day, monitor for gastrointestinal adverse reactions. This medication is an orally disintegrating tablet that can be taken by placing it on the tongue and allowing it to dissolve, either with water or without.

Child dose

There is no experience with use in children.

This medication contains Donepezil Hydrochloride as the main ingredient and is used to help improve the symptoms of patients with Alzheimer's type dementia. First, this medication should not be used by individuals who are allergic to Donepezil Hydrochloride or any components contained in this medication, nor by pregnant or breastfeeding women. Individuals with heart-related diseases or those with a slow heart rate should be particularly cautious when using this medication, as it may further slow the heart rate or cause arrhythmias. Those with a history of peptic ulcers or who are taking nonsteroidal anti-inflammatory drugs should exercise caution due to the potential for gastrointestinal bleeding or exacerbation of ulcers. Patients with asthma or obstructive lung disease should be careful, as this medication can constrict the muscles of the airways or increase mucus secretion, potentially worsening symptoms. Patients with extrapyramidal disorders, such as Parkinson's disease, should use this medication cautiously as their symptoms may worsen. During the use of this medication, symptoms such as fainting, heart problems, gastrointestinal bleeding, liver function abnormalities, seizures, and muscle abnormality symptoms may appear, so it is important to consult a healthcare professional immediately if symptoms occur. Additionally, this medication can cause various side effects such as drowsiness, dizziness, insomnia, loss of appetite, nausea, diarrhea, and it is important to consult a doctor if any symptoms are severe, even if some symptoms are temporary. This medication may trigger specific heart arrhythmias, so patients with a history of heart disease or a history of QT interval prolongation may require an ECG. Pregnant or breastfeeding women are advised to avoid this medication; if it must be used, breastfeeding should be discontinued. The safety of this medication has not been established in children, and it should not be used in pediatric patients. Caution is necessary while driving or operating machinery as drowsiness or dizziness may occur, especially at the beginning of treatment or when the dosage is changed. This medication may interact with other drugs; therefore, it is important to inform healthcare professionals when taking it, especially when combined with heart medications, antibiotics, antidepressants, antipsychotics, and anti-inflammatory pain relievers. In case of overdose, there is a risk of severe nausea, vomiting, bradycardia, hypotension, and respiratory depression, necessitating immediate emergency treatment, and atropine may be used as an antidote. Lastly, this medication should be taken by dissolving it in the mouth as an orally disintegrating tablet, kept out of reach of children, and protected from direct sunlight.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, high fever accompanied by severe rash, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough+fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headaches, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, urination.

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• drowsiness
• dizziness
• insomnia
• anxiety

This medication should be stored in a sealed container to prevent air and moisture from entering, and it is recommended to store it at room temperature between 1 to 30 degrees Celsius.

Appearance

Yellow circular orally disintegrating tablet

Package unit

30 tablets (10 tablets/PTP packaging x 3)