Medication info

Evatorex Tablet 10/10

Prescription medicationTablet경구
Ingredient · strength
Ezetimibe›10mg / 1 tabletSimvastatin›10mg / 1 tablet
Manufacturer / importer
(주)에이프로젠바이오로직스
Appearance
White to pale yellow, bilaterally convex oblong tablets
Packaging
30 tablets/Alu-Alu packaging (10 tablets/Alu-Alu x 3)
Approval status
Active

MFDS item code 201603655 · Approved 2016.06.21

Summary

Main use
Improvement of cholesterol and lipids in hypercholesterolemia (primary, homozygous familial) and mixed hyperlipidemia
Who takes it
Adults
Adult dose
This medication is administered once daily in the evening, regardless of meals. For patients with primary hypercholesterolemia: the dosage ranges from 10/10 mg to 10/40 mg per day, with a generally recommended starting dose of 10/20 mg per day. Patients with less need for LDL cholesterol reduction may start with 10/10 mg once daily. The recommended dose for patients with homozygous familial hypercholesterolemia is 10/40 mg once daily.

Ingredients

Manufacturer
(주)에이프로젠바이오로직스

Efficacy & effects

Improvement of cholesterol and lipids in hypercholesterolemia (primary, homozygous familial) and mixed hyperlipidemia

  • Primary hypercholesterolemia
  • heterozygous familial hypercholesterolemia
  • non-familial hypercholesterolemia
  • mixed hyperlipidemia
  • homozygous familial hypercholesterolemia
  • atherosclerotic vascular diseases caused by hypercholesterolemia
  • dyslipidemia
  • diabetes
  • hypothyroidism
  • obstructive liver disease
  • chronic renal failure
  • increased LDL cholesterol
View approved original text

This medication helps lower total cholesterol, LDL cholesterol, and triglyceride levels in patients with primary hypercholesterolemia and mixed hyperlipidemia and increases the levels of good cholesterol, HDL cholesterol. It is also used as an adjunctive therapy when concurrent or alternative treatment is difficult for patients with homozygous familial hypercholesterolemia. This medication should be taken with an appropriate diet, and it is important to first identify and treat any secondary causes such as diabetes or hypothyroidism. Regular monitoring of blood lipid levels is recommended during treatment to assess effectiveness, especially for patients who have had an acute coronary event where measurement soon after hospitalization is advised. This medication is effective in reducing the risk of hypercholesterolemia and related cardiovascular diseases.

How to take

Adult dose

This medication is administered once daily in the evening, regardless of meals. For patients with primary hypercholesterolemia: the dosage ranges from 10/10 mg to 10/40 mg per day, with a generally recommended starting dose of 10/20 mg per day. Patients with less need for LDL cholesterol reduction may start with 10/10 mg once daily. The recommended dose for patients with homozygous familial hypercholesterolemia is 10/40 mg once daily.

Precautions

This medication may cause serious muscle-related side effects such as myopathy and rhabdomyolysis; therefore, immediately inform your doctor if you experience muscle pain or weakness. This medication should not be administered to certain patients, including those with an allergy to its ingredients, severe liver dysfunction, pregnant or breastfeeding women, and patients taking specific medications. Additionally, patients with myasthenia gravis or ocular myasthenia gravis should exercise special caution when using this medication, and discontinue if symptoms worsen. Patients with liver dysfunction should undergo liver function tests before taking this medication, and liver function should be monitored regularly during treatment. If symptoms of liver damage appear, use should be discontinued immediately. This medication can interact with several drugs, increasing the risk of myopathy, especially if taken with some antifungals, antibiotics, immunosuppressants, or certain heart medications, so it’s crucial to inform your doctor about all medications you are taking. Women who are pregnant or may become pregnant should not take this medication, and if pregnancy is confirmed, they should stop taking it immediately. Breastfeeding women should also cease breastfeeding while taking this medication. For children and adolescents, safety and efficacy have not been adequately established, so it is generally not recommended except in special cases. Elderly patients may react more sensitively to this medication, and caution should be exercised in their administration. In case of overdose, there is no specific antidote, and appropriate treatment should be administered based on symptoms. Finally, it is important to undergo regular blood tests and muscle-related examinations during treatment to detect any abnormal signs early.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, mouth/eye mucosa pain, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme malaise, sudden and severe headache, thunderclap headache, seizures, confusion, vision abnormalities, paralysis, urination

Mild side effects

  • Headache
  • diarrhea
  • influenza
  • upper respiratory tract infections
  • muscle pain
  • limb pain
  • fatigue
  • abdominal pain
  • pharyngitis
  • sinusitis
Show 28 more
  • arthralgia
  • low back pain
  • cough
  • weakness
  • cataracts in the eye
  • constipation
  • dyspepsia
  • flatulence
  • nausea
  • eczema
  • itching
  • rash
  • tremor
  • dizziness
  • paresthesia
  • peripheral neuropathy
  • peripheral neuropathy
  • psychiatric disorders
  • anxiety
  • sleep disturbances
  • depression
  • cognitive impairment
  • interstitial lung disease
  • thrombocytopenia
  • vomiting
  • pancreatitis
  • headache
  • bile

Not everyone experiences these, and they can vary from person to person.

Storage

This medication is sensitive to air and moisture; thus, it should be kept tightly sealed. It is also recommended to store it at room temperature, between 1 and 30 degrees Celsius. This will help maintain the effectiveness of the medication over time.

Appearance and packaging

Appearance

White to pale yellow, bilaterally convex oblong tablets

Package unit

30 tablets/Alu-Alu packaging (10 tablets/Alu-Alu x 3)

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

No questions yet.

For anything that needs medical judgment, consult a doctor or pharmacist.

Related searches

Search tags

Suggested searches

This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.