DIAFOLMIN XR Prolonged Release Tablet 750 mg (Metformin Hydrochloride)

Adult dose

The typical initial dose is 500 mg of Metformin Hydrochloride prolonged release tablets administered once daily with the evening meal. After one week, blood sugar levels should be measured to adjust the dosage. When increasing the dose, it should be increased by 500 mg weekly, with a maximum daily dose of 2000 mg also to be taken with the evening meal. If a maximum of 2000 mg taken once daily does not achieve blood sugar control, consider administering 1000 mg twice daily.

This medication can rarely cause a serious condition called lactic acidosis, so caution is needed when using it. Particularly when used with other diabetes drugs such as insulin or sulfonylureas, symptoms of hypoglycemia may occur, so care should be taken. Patients with moderate to severe impairment of kidney function, dehydration, severe infections, or acute conditions such as acute myocardial infarction should not use this medication. Also, patients with acute and unstable heart failure, those scheduled for tests using radioactive iodine contrast agents, and those with allergies to this medication or biguanide medications should not be administered this drug. Caution is also necessary for type 1 diabetes patients, patients with a history of ketoacidosis, patients with severe infections or trauma, patients scheduled for surgery, patients with malnutrition or liver dysfunction. Renal function should be regularly monitored during the use of this medication to ensure that the drug does not accumulate excessively in the body. Irregular meals, vigorous exercise, and interactions with other drugs may increase the risk of lactic acidosis or hypoglycemia, so care should be taken. Side effects may include gastrointestinal disorders (nausea, vomiting, diarrhea, etc.), vitamin B12 deficiency, and taste disturbances. If symptoms are severe, consult a physician. During pregnancy, use should be approached cautiously under a doctor's judgment regarding fetal impacts, and it is not recommended during breastfeeding. Elderly patients often experience a decline in kidney function, so dosage adjustments and regular monitoring of kidney function are necessary. Although hypoglycemia is rare in case of overdose, there is a risk of lactic acidosis, so immediate medical attention is required. This medication must be taken as prescribed, and tablets should not be crushed or chewed but swallowed whole. Furthermore, alcohol consumption may increase the risk of lactic acidosis, so it is advisable to avoid drinking alcohol while taking this medication. The hypoglycemic effect may vary depending on other medications taken alongside; therefore, patients should inform healthcare professionals of any other medications they are taking. Finally, regular monitoring of blood sugar and kidney function, and checking vitamin B12 levels is important while on this medication, and patients should immediately consult healthcare professionals if any abnormal symptoms arise.

Serious side effects

Lactic acidosis, severe allergic reactions (hives, severe swelling), serious neurological symptoms (seizures, confusion), severe edema and urination abnormalities (symptoms related to renal function decline)

Mild side effects

• Vitamin B12 deficiency
• taste impairment
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• erythema
• itching
• hives

Store this medication in a tightly closed container to prevent air or moisture ingress. Additionally, it is safest to store the medication at room temperature, which is not too hot or too cold, preferably between 1°C and 30°C.

Appearance

White, oblong prolonged release tablet

Package unit

30 tablets/bottle, 300 tablets/bottle