Crezin Tablet 20 Milligrams (Rosuvastatin Calcium)

Adult dosage

For patients with primary hypercholesterolemia, mixed hyperlipidemia, primary dysbetalipoproteinemia, and homozygous familial hypercholesterolemia, it is administered once daily at a starting dose of 5 milligrams, irrespective of meals. If greater reduction of LDL-cholesterol is needed, the maintenance dose can be adjusted to 10 milligrams once daily, with monitoring every 4 weeks or more based on the patient's condition, up to a maximum of once daily.

Children's dosage

In pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17), it is administered once daily within the range of 5 milligrams to 20 milligrams, adjusted according to individual treatment goals at intervals of at least 4 weeks.

This medication should not be used in certain patients. Individuals allergic to any components of this drug, those with severely impaired liver function, patients with muscle diseases, and those taking certain medications should avoid its use. It is also not safe for pregnant or breastfeeding women, as well as fertile women not using adequate contraception. Additionally, high-dose usage is prohibited in patients at risk of muscle disease. This drug contains lactose, so patients with genetic issues like lactose intolerance should refrain from taking it. When taking this drug, it's essential to monitor liver function tests and watch for muscle-related symptoms. Patients who consume alcohol excessively or have a history of liver disease should exercise particular caution, and it is advisable to undergo liver function tests before and during treatment. Patients experiencing symptoms such as muscle pain or weakness should promptly inform their physician, and discontinuation of this medication may be necessary. Furthermore, patients with impaired kidney function, the elderly, or those with hypothyroidism, who are at higher risk for muscle complications, should use this medication more cautiously. Rarely, side effects such as skin rash, headaches, indigestion, muscle pain may occur while taking this drug. In severe cases, serious side effects such as liver dysfunction, muscle damage, or very rarely, severe skin reactions may arise; thus, it is important to consult medical personnel if symptoms develop. This drug may interact with other medications, so you must inform your healthcare provider of any other drugs you are currently taking. Particularly, the risk of muscle damage may increase when used in conjunction with certain antiviral agents, immunosuppressants, antifungal agents, antibiotics, and specific lipid-lowering medications. Pregnant or breastfeeding women should avoid this medication, and women who may become pregnant should use proper contraceptive methods. In case of overdose, there is no specific antidote, so treatment should be symptomatic while monitoring liver function and muscle enzyme levels. Caution is needed while driving or operating machinery, as dizziness may occur. This medication may have increased systemic concentration in Asians, so dosage adjustments may be necessary. Before using this drug, consultation with a physician or pharmacist is essential to disclose personal health conditions and other medications being taken.

Serious side effects

Allergic reactions including urticaria and angioedema, rhabdomyolysis, severe muscle weakness, ophthalmoplegia, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), acute renal failure, oliguria, thrombocytopenia, jaundice, hepatitis, fatal and non-fatal liver failure, severe allergic reactions, severe skin reactions, respiratory distress

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• rash
• myalgia
• weakness
• hematuria

This drug should be stored in a tightly sealed container to prevent air or moisture from entering. It is recommended to store at room temperature between 1 and 30 degrees Celsius.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle