Actofin Tablet (Pioglitazone Hydrochloride)

Adult dose

This medication is administered orally once a day, regardless of meals. It is started at 15 mg once a day as monotherapy and may be increased to 30 mg once a day if sufficient effect is not achieved. In combination therapy, 15 mg is also administered once a day, with a maximum recommended dose not exceeding 30 mg once a day.

Child dose

There is no experience with the use in children under 18 years, so administration is not recommended.

This medication is used to treat Type 2 Diabetes and works with insulin to help regulate blood sugar levels. When taking this medication, heart failure may develop or worsen; therefore, if symptoms such as sudden weight gain, shortness of breath, or swelling occur, it is vital to inform healthcare professionals immediately. Patients with heart failure should not use this medication, and caution should be exercised for patients at high risk of heart failure. This medication may cause fluid retention leading to swelling; thus, it is essential to consult healthcare professionals if swelling symptoms appear. Patients with a history of bladder cancer or current active bladder cancer should not take this medication, and if gross hematuria or urinary disorders occur, they must inform their doctor immediately. Liver function may be affected, so regular liver function tests should be performed before and during treatment, and any symptoms of liver dysfunction should be reported to healthcare professionals immediately. Using this medication with other hypoglycemic agents may increase the risk of hypoglycemia; therefore, understanding the symptoms of hypoglycemia and how to respond is essential, and dosage adjustments of other medications may be necessary. Women who are pregnant or may become pregnant should consult their doctor before taking this medication, and premenopausal women may need to use appropriate contraceptive methods due to the increased risk of pregnancy while taking this medication. Elderly patients or those with impaired renal or liver function should use this medication with greater care and should follow the instructions of their healthcare provider. Additionally, this medication may not exhibit special symptoms in the case of overdose, but if an overdose is suspected, immediate notification to healthcare professionals and appropriate treatment is required. This medication has not been confirmed for safety and efficacy in children, so it is not used in this population. Finally, this medication should be stored in a designated container and kept out of reach of children, and it should be taken once daily; if a dose is missed, one must be careful not to take double the dose the next day.

Serious side effects

Congestive heart failure, signs and symptoms of heart failure (including excessive and rapid weight change, difficulty breathing, and swelling), edema (including severe edema, peripheral edema, generalized edema, pitting edema, and fluid retention), severe allergic reactions (urticaria), liver dysfunction (including liver function impairment and liver failure, increased liver enzymes, and symptoms of jaundice), bladder cancer, hypoglycemia (including severe hypoglycemia), severe neurological symptoms (such as stroke, myocardial infarction, etc.)

Mild side effects

• Upper respiratory tract infection
• headache
• sinusitis
• myalgia
• pharyngitis
• abdominal distension
• weight gain
• urinary tract infection
• back pain
• dizziness

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is best to maintain a storage temperature between 1 degree and 30 degrees Celsius. Proper storage will ensure the medication retains its effectiveness.

Appearance

White to grayish-white, convex cylindrical tablets

Package unit

30 tablets/bottle, 100 tablets/bottle