Boriato Tablets (Atorvastatin Calcium Trihydrate)

Adult dosage

The recommended initial dose for the treatment of hyperlipidemia is 10 mg once daily; for patients requiring greater LDL cholesterol reduction, it may begin at 20 mg or 40 mg once daily. Doses should be administered within the range of 10-80 mg once daily, individualized based on treatment goals and responses. Lipid levels should be checked within 2-4 weeks after starting treatment and adjusting doses. The goal of treatment is to lower LDL cholesterol levels, so it is recommended to use LDL cholesterol for assessing the response to treatment. If LDL cholesterol levels cannot be measured, total cholesterol levels should be used to monitor the treatment response. For patients with homozygous familial hypercholesterolemia, the dosage should be 10-80 mg once daily, either alongside other lipid-lowering therapies (e.g., LDL apheresis) or if such therapies are not possible. 2. Pediatric patients (aged 10-17 years) with heterozygous familial hypercholesterolemia The recommended initial dose is 10 mg once daily, with a recommended maximum dose of 20 mg daily (there is no clinical data on administering doses greater than 20 mg in the pediatric population). The dose should be adjusted according to the recommended treatment goals for each patient. Doses should be adjusted at intervals of 4 weeks or more. ○ Patients with renal impairment: Renal disease does not affect the plasma concentration of atorvastatin or its LDL cholesterol-lowering effect, so there is no need to adjust dosages. ○ Elderly: Efficacy and safety for patients aged 70 and older are generally similar to those in the regular adult population.

Children's dosage

The recommended initial dose for pediatric patients (aged 10-17 years) with heterozygous familial hypercholesterolemia is 10 mg once daily, with a maximum dose of 20 mg daily. Doses should be adjusted at intervals of at least 4 weeks based on treatment goals.

This medication may cause muscle-related symptoms, so patients should immediately inform their doctor if they experience muscle pain, weakness, or severe fatigue. Prior to taking this medication, it is essential to check for any allergic reactions or liver and muscle diseases. Women who are pregnant or breastfeeding should not take this medication. As this medication may affect liver function, regular liver function tests should be conducted, and if symptoms of hepatitis or jaundice occur, the medication should be discontinued. The risk of side effects may increase when this medication is taken with certain other drugs, so it is crucial to inform the doctor or pharmacist of any medications currently being taken. Elderly patients or those with impaired renal function are at a higher risk for muscle disease and require caution during use, and should consult healthcare professionals if symptoms arise. Avoid excessive alcohol consumption and limit the intake of certain foods such as grapefruit juice while taking this medication. Women who may become pregnant should use appropriate contraception while taking this medication, and if pregnancy is confirmed, the medication must be discontinued immediately. Children and those under 10 years of age should not use this medication, and adolescents aged 10 years and older should follow professional guidance. This medication can cause severe muscle side effects such as myopathy or rhabdomyolysis, so if significant muscle pain or weakness occurs, healthcare professionals should be informed immediately. In cases of overdose, there is no specific antidote, treatment should depend on symptoms, and liver function and muscle condition should be checked regularly. Store this medication out of reach of children and keep it in its original container for safety.

Serious side effects

Hives, severe swelling (including angioedema), chest tightness, difficulty breathing, cold sweat, paleness, severe allergic reactions, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, severe skin reactions, asthma attacks, difficulty breathing, respiratory issues, jaundice (yellowing of the skin or eyes), extreme lethargy, liver dysfunction (jaundice), sudden and severe headaches, lightning-type headache

Mild side effects

• Weakness
• lethargy
• chest pain
• peripheral edema
• fatigue
• fever
• nasopharyngitis
• hyperglycemia
• hypoglycemia
• weight gain

This medication should be stored in a tightly sealed container to prevent air and moisture from entering, ideally at a temperature between 1°C and 30°C (33.8°F and 86°F). Storing it this way helps maintain the medication's effectiveness and prevents degradation.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle