Genupharm Donepezil Hydrochloride Tablet 10 mg

Adult dose

Adults: Administer 5 mg of Donepezil Hydrochloride once daily before bedtime. If unusual dreams, nightmares, or sleep disturbances occur, consider morning dosing of this medication. Donepezil concentration reaches steady state 15 days after administration, and the frequency of adverse reactions may be influenced by the rate of dose increase; therefore, administer 5 mg for 4 to 6 weeks. After evaluating the clinical response during this period, the dose may be increased to 10 mg. When increasing to 10 mg, pay attention to gastrointestinal adverse reactions.

Child dose

Pediatric: There is no experience with the use in children.

This medication is used to treat Alzheimer's type dementia symptoms with Donepezil Hydrochloride as the main ingredient. First, this medication should not be used in certain patients. For example, patients allergic to this medication or its components, pregnant women or women who may become pregnant, nursing mothers, as well as those with lactose intolerance or specific genetic lactose metabolism disorders should not take this medication. Additionally, patients with heart disease or heart conduction disorders, those with a history of peptic ulcers or taking non-steroidal anti-inflammatory drugs, patients with a history of asthma or obstructive lung disease, and patients with extrapyramidal disorders like Parkinson's disease should use this medication cautiously. Patients allergic to the yellow No. 5 dye included in this medication should also exercise caution. Various adverse reactions may occur while taking this medication. Rarely, arrhythmias, gastrointestinal bleeding, liver dysfunction, cerebrovascular issues, motor dysfunction, muscle symptoms, shortness of breath, acute pancreatitis, and acute renal failure have been reported. More commonly, nausea, vomiting, diarrhea, dizziness, insomnia, headache, and fatigue may occur. Particularly, it may impact the cardiovascular system, so patients with a history of heart disease need regular monitoring, including an electrocardiogram. Also, as there is a risk of gastrointestinal bleeding, patients with a history of peptic ulcers or those taking anti-inflammatory drugs should carefully observe any symptoms. This medication might affect the ability to drive or operate machinery, so caution is required as dizziness or fatigue may occur at the beginning of treatment or with dose changes. Women who are pregnant or nursing are advised not to use this medication and should consult a specialist if absolutely necessary. This medication can interact with various other medications, so those taking other medications must inform their healthcare provider. Caution is particularly important when taken with certain antibiotics, antidepressants, antiarrhythmic agents, and antipsychotic medications as the risk of arrhythmias can increase. In case of overdose, symptoms such as nausea, vomiting, bradycardia, respiratory depression, and muscle weakness may appear, requiring immediate treatment at a medical institution. Atropine can be used as an antidote. Finally, this medication should be kept out of reach of children, and it is safest not to transfer it to another container.

Serious side effects

Syncope, bradycardia, heart block, QT interval prolongation, Torsades de Pointes, myocardial infarction, heart failure, peptic ulcer, perforated duodenal ulcer, gastrointestinal bleeding, hepatitis, liver dysfunction, jaundice, cerebral seizures (epilepsy, convulsions, etc.), cerebral hemorrhage, cerebrovascular disorders, extrapyramidal disorders, neuroleptic malignant syndrome, rhabdomyolysis, shortness of breath, acute pancreatitis, acute renal failure, cause unknown

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• drowsiness
• insomnia
• dizziness
• anxiety

Store this medication in a tightly sealed container to prevent air or moisture from entering, and it is advisable to keep it at a temperature between 1 degree and 30 degrees Celsius (room temperature). This way of storage will help maintain the effectiveness of the medication.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle