Sitagliptin Tablets 50mg (Sitagliptin Phosphate)

Adult dose

The recommended dose for this medication is 100 mg once daily, whether used as monotherapy or in combination therapy, with the maximum daily dose being 100 mg. It can be taken without regard to meals. In patients with renal impairment, dose adjustments may be needed based on kidney function. - Glomerular filtration rate of 30-45 mL/min/1.73 m2: administer 50 mg once daily. - Glomerular filtration rate of 15-30 mL/min/1.73 m2 or ESRD patients: 25 mg once daily.

This medication is used for the treatment of diabetes and may lead to severe allergic reactions during use, so caution is required. If any hypersensitivity reactions such as skin rash or breathlessness occur within three months of starting the medication, treatment should be stopped immediately. Additionally, since it may induce acute pancreatitis, characterized by severe inflammation of the pancreas, patients should promptly consult with healthcare providers if they experience abdominal pain, nausea, or vomiting during treatment. It is not to be used in patients with type 1 diabetes or diabetic ketoacidosis, and should be avoided in individuals allergic to this medication or its components. Patients with poor kidney function may experience increased drug concentration, necessitating dose adjustments, and regular kidney function assessments before and after administration are critical. Care should be taken when taking this medication to avoid hypoglycemia, especially when used in conjunction with insulin or sulfonylureas; adjustments to the doses of such medications may be needed if necessary. Rarely, side effects such as arthralgia or skin blisters have been reported, and should such symptoms occur, immediate consultation with a physician is advised. Pregnant or breastfeeding women are advised against the use of this medication. Elderly patients may be at risk for decreased kidney function, so dose adjustments and kidney function evaluations are needed. Overdosing may require emergency treatment, and this drug can be partially removed by hemodialysis. There is a potential for drug interactions during treatment, so patients must inform their healthcare provider of any other medications they are currently taking.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, severe skin reactions (Stevens-Johnson syndrome, exfoliative dermatitis), acute pancreatitis (including hemorrhagic or necrotizing), dyspnea, acute kidney failure, liver abnormalities (increased liver enzymes, suspected symptoms of jaundice), severe neurological symptoms (headache, seizures, consciousness disturbances, etc.), severe edema, arthritis with severity and disability, bullous pemphigoid, rhabdomyolysis, hypoglycemia

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• diarrhea
• nausea
• dyspepsia
• dizziness
• myalgia
• limb pain
• back pain

This medication should be stored in a tightly sealed container to prevent air from entering, at room temperature between 1 and 30 degrees Celsius. Stored this way, the efficacy of the medication can be maintained for an extended period.

Appearance

Light beige, bilaterally convex, round film-coated tablet

Package unit

30 tablets (10 tablets/PTP*3)