Esomark 20 mg (Esomeprazole Magnesium Trihydrate)

Adult dosage

This medicine should be swallowed with a liquid such as water and must not be chewed or crushed. 1. Adults 1) Gastroesophageal reflux disease (GERD). - Treatment of erosive reflux esophagitis: Administer 40 mg once daily for 4 weeks. Patients whose esophagitis has not healed or whose symptoms persist should take the medicine for an additional 4 weeks. - Long-term maintenance therapy to prevent recurrence in patients with esophagitis: 20 mg once daily - Symptomatic treatment of gastroesophageal reflux disease without esophagitis: · 20 mg once daily. If symptoms are not controlled after 4 weeks, further evaluation is needed. · Once symptoms have resolved, subsequent recurrent symptoms may be controlled by administering 20 mg once daily. · In adults, 20 mg may be administered once daily as needed. As-needed administration is not recommended for controlling recurrent symptoms in patients at high risk of developing gastric or duodenal ulcers due to treatment with nonsteroidal anti-inflammatory drugs. 2) Combination therapy with antibiotics for eradication of Helicobacter pylori Administer this medicine 20 mg with amoxicillin 1 g and clarithromycin 500 mg 2 times daily for 7 days. 3) Short-term treatment of upper gastrointestinal symptoms (pain, discomfort, burning sensation) associated with use of nonsteroidal anti-inflammatory drugs (nonselective or selective COX-2 inhibitors) - 20 mg once daily. If symptoms are not controlled after 4 weeks, further evaluation is needed. No clinical trials exceeding 4 weeks have been conducted. 4) Patients requiring continuous treatment with nonsteroidal anti-inflammatory drugs - Treatment of gastric ulcers associated with use of nonsteroidal anti-inflammatory drugs: 20 mg once daily. The treatment period is 4∼8 weeks. - Prevention of gastric and duodenal ulcers associated with use of nonsteroidal anti-inflammatory drugs: 20 mg once daily. 5) Treatment of Zollinger-Ellison syndrome The recommended initial dose is 40 mg 2 times daily. The dose should then be adjusted individually, and treatment should continue while clinical symptoms are present. According to clinical data, most patients can be controlled with doses of 80 ∼ 160 mg daily. Doses above 80 mg daily should be divided into 2 doses. 6) Maintenance therapy following intravenous induction to prevent rebleeding due to gastric or duodenal ulcers Administer 40 mg once daily for 4 weeks following intravenous induction to prevent rebleeding due to gastric or duodenal ulcers. 4. Renal impairment No dose adjustment is necessary. Use with caution because there is limited experience administering this medicine to patients with severe renal impairment. 5. Hepatic impairment No dose adjustment is necessary in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, the dose of this medicine should not exceed 20 mg. 6. Older adults No dose adjustment is necessary.

Children's dosage

2. Adolescents aged 12 years and older 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive reflux esophagitis: Administer 40 mg once daily for 4 weeks. For patients whose esophagitis has not healed or whose symptoms persist, continue treatment for an additional 4 weeks. - Symptomatic treatment of gastroesophageal reflux disease without esophagitis: · 20 mg once daily. If symptoms are not controlled after 4 weeks, further medical evaluation is needed. · Once symptoms have been relieved, subsequent recurrent symptoms are controlled by administering 20 mg once daily. 3. Children under 12 years of age There is no experience with administering this drug to children under 12 years of age.

This medication should not be given to patients who are allergic to certain components or benzimidazoles. Patients with allergies to penicillin or macrolide antibiotics should also be cautious. It is advisable for nursing women and patients with a history of myocardial infarction not to use this medication. Various adverse reactions may occur during treatment, so symptoms should be monitored. Gastrointestinal symptoms such as headache, abdominal pain, diarrhea, nausea, and vomiting are frequently reported, and sometimes dizziness or insomnia may occur. Rarely, serious side effects such as skin rash, fever, blood disorders, and liver dysfunction may occur; if any abnormal symptoms occur, immediately consult a doctor. Long-term usage requires regular examinations, such as blood tests, particularly when used for more than one year, as there is a risk of electrolyte abnormalities like hypomagnesemia. This medication has many interactions with other drugs, so if taking additional medications, it is essential to inform your doctor or pharmacist. Caution is necessary when used with antiviral agents, anticoagulants, or anticonvulsants. Data regarding the safety of this medication during pregnancy is limited, so it is necessary to consult a doctor before taking it if pregnant. When breastfeeding, the possibility of this drug passing into breast milk means that it is best to avoid its use. In case of overdose, there is no specific antidote, so one must go to the hospital immediately for appropriate treatment, and keep it out of reach of children.

Leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, fever, angioedema, anaphylactic reaction, shock, peripheral edema, hyponatremia, hypomagnesemia, insomnia, anxiety, mental confusion, depression, aggression, hallucination, headache, dizziness, paresthesia, drowsiness, taste disturbances, blurred vision, bronchospasm, pancreatitis, abdominal pain, constipation, diarrhea, abdominal bloating, nausea, vomiting, dry mouth, stomatitis, gastrointestinal candidiasis, microscopic colitis, increased liver enzymes, jaundice, hepatitis, liver failure, encephalopathy, dermatitis, itching, rash, urticaria, hair loss, photosensitivity, erythema multiforme, mucous membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Leel syndrome, acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms, fracture, arthralgia, myalgia, muscle weakness, interstitial nephritis, gynecomastia, asthenia, increased sweating, Clostridium difficile-associated diarrhea, abdominal distension, allergic reaction, back pain, chest pain, sternal pain, facial edema, facial flushing, fatigue, fever, flu-like symptoms, generalized edema, leg edema, malaise, pain, stiffness, peripheral edema, flushing, hypertension, tachycardia, goiter, irritable bowel syndrome, worsening constipation, dyspepsia, dysphagia, gastrointestinal malformation, epigastric pain, belching, esophageal disorder, frequent bowel movements, gastroenteritis, gastrointestinal bleeding, hiccups, black stools, oral disorders, pharyngeal disorders, rectal disorders, gastrointestinal symptoms, increased gastrin levels in the blood, tongue disorders, tongue edema, ulcerative stomatitis, vomiting, ear pain, tinnitus, anemia, hypopigmented anemia, cervical lymphadenopathy, nosebleeds, leukocytosis, leukopenia, thrombocytopenia, hyperbilirubinemia, liver dysfunction, increased ALT, increased AST, diabetes, hyperuricemia, increased ALP, thirst, vitamin B12 deficiency, weight gain, weight loss, exacerbated arthritis, arthropathy, seizures, fibromyalgia, hernia, rheumatoid polymyalgia, arthralgia, appetite loss, apathy, increased appetite, confusion, worsening depression, hypertonia, anxiety, sensory loss, erectile dysfunction, insomnia, migraine, exacerbated migraine, sleep disorders, tremors, dizziness, visual field loss, paresthesia, drowsiness, dysmenorrhea, menstrual disorders, vaginitis, exacerbated asthma, cough, dyspnea, laryngeal edema, pharyngitis, rhinitis, sinusitis, acne, anal itching, rash, erythematous rash, papular rash, angioedema, dermatitis, itching, urticaria, increased sweating, otitis media, altered olfactory sensation, loss of taste, gustatory dysfunction, urinary abnormalities, albuminuria, cystitis, dysuria, fungal infection, hematuria, frequency of urination, candidiasis, genital candidiasis, polyuria, conjunctivitis, visual disturbances, duodenitis, esophagitis, esophageal stricture, esophageal ulcer, esophageal varices, gastric ulcer, gastritis, benign polyps or nodules, Barrett's esophagus, mucosal discoloration, hernia, systemic lupus erythematosus, discoid lupus erythematosus, gastric fundus polyp, hypocalcemia, hypokalemia, rhabdomyolysis, myalgia, asthenia

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. It is also advisable to store it at room temperature, which should not be too hot or too cold, ideally between 1°C and 30°C.

Appearance

Pale pink, round film-coated tablet

Package unit

28 tablets/box [(14 tablets/Alu-Alu x 2)]