Arison Tablets 10mg (Donepezil Hydrochloride Monohydrate)

Adult dose

For donepezil hydrochloride, the recommended dose is 5 mg once daily before bedtime. A 5 mg dose is administered for about 4-6 weeks, and after assessing clinical response, the dose can be increased to 10 mg. When increasing to 10 mg daily, caution should be observed for gastrointestinal adverse reactions. For underweight women aged 85 and older, should not exceed 5 mg daily and requires careful monitoring.

Child dose

There is no experience in using this medication in children.

This medication contains donepezil hydrochloride as the main ingredient and is primarily used to relieve the symptoms of Alzheimer's dementia. This medication should not be administered to certain patients, including those allergic to donepezil hydrochloride or any ingredient in this medication, pregnant women or women who may become pregnant, and nursing mothers. Individuals with genetic disorders that prevent the digestion of lactose should also avoid this medication. Patients with heart disease or conduction disorders may experience bradycardia or arrhythmias when taking this medication, so caution is necessary. Additionally, those with a history of peptic ulcers or those taking non-steroidal anti-inflammatory drugs should be carefully monitored due to an increased risk of gastrointestinal bleeding. Those with asthma or chronic obstructive pulmonary disease may also experience worsening symptoms from this medication. This medication may aggravate symptoms in patients with extrapyramidal disorders such as epilepsy or Parkinson's disease, hence it must be used with caution. Individuals allergic to tartrazine should also be cautious when using this medication. Various adverse reactions may occur with this medication, and in severe cases, symptoms such as fainting, heart block, gastrointestinal bleeding, liver dysfunction, cerebrovascular problems, and muscle abnormal symptoms may arise. If these symptoms occur, immediate consultation with a physician is required. Commonly reported side effects include dizziness, nausea, vomiting, diarrhea, insomnia, headache, fatigue, and in some patients, psychiatric symptoms such as hallucinations or aggressive behavior may also appear. This medication is approved for use only in Alzheimer's dementia and should not be used for other forms of dementia or memory disorders. Administration should occur under the diagnosis and supervision of a specialist, and discontinuation should be considered if therapeutic effects are not observed. Due to its potential impact on the heart, patients with heart diseases or a history of QT interval prolongation may require regular ECG monitoring. In addition, this medication may enhance the effects of muscle relaxants during anesthesia, so it is imperative to inform the physician prior to anesthesia. This medication is metabolized in the liver, so caution is needed for patients with impaired liver function or those taking medications that affect CYP3A4 or CYP2D6 enzymes, as there may be changes in efficacy. Additionally, interactions may occur when taken with other cholinergic or anticholinergic medications. Pregnant and nursing women are advised not to take this medication unless absolutely necessary, and such cases should be discussed with a healthcare professional. Safety in children has not been established, so it should not be used in pediatric patients. In case of overdose, severe nausea, vomiting, sweating, bradycardia, respiratory depression, and seizures may occur, so immediate hospital visit for appropriate treatment is necessary, and atropine may be used as an antidote. This medication should be kept out of reach of children and not transferred to other containers as this is beneficial for maintaining quality.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, pain in oral/eye mucosa, shortness of breath or difficulty breathing, asthma attack, abnormal breathing with cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• dizziness
• insomnia
• drowsiness
• muscle cramps

This medication should be stored in a sealed container to prevent air or moisture from entering, at a temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication for a longer period.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle