Donepezil Hydrochloride 10 mg (Donepezil Hydrochloride Monohydrate)

Adult dose

Administer 5 mg once daily before bedtime as Donepezil Hydrochloride. Maintain the dose of 5 mg for 4-6 weeks while assessing clinical response, after which it may be increased up to 10 mg. If increasing to 10 mg daily, monitor closely for gastrointestinal adverse reactions. Underweight female patients over 85 years should not exceed 5 mg daily and require careful monitoring.

Child dose

There is no experience of use in pediatric patients.

This medication contains Donepezil Hydrochloride Monohydrate as its active ingredient and is used to treat Alzheimer-type dementia symptoms. This medication should not be used in certain patients. For example, individuals allergic to this medication or its components, pregnant women or women who may become pregnant, and nursing mothers should not take this medication. Additionally, this medication contains lactose and should not be given to patients with lactose intolerance or certain genetic metabolic disorders. Patients with heart diseases or specific cardiac conduction disorders should be careful when using this medication as they may experience bradycardia or arrhythmia. Patients taking non-steroidal anti-inflammatory drugs or with a history of peptic ulcer should use this medication with caution as it may increase gastric acid secretion and accelerate gastrointestinal motility, potentially worsening ulcer symptoms. Patients with a history of asthma or obstructive lung disease should be cautious as this medication may cause bronchoconstriction or increased mucus secretion, worsening symptoms. Patients with extrapyramidal disorders such as Parkinson's disease should use this medication with caution due to its cholinergic effects which may exacerbate symptoms. This medication contains Yellow No. 5 dye, and caution is advised for individuals allergic to this component. During the administration of this medication, adverse reactions related to the heart may include fainting, bradycardia, heart block, myocardial infarction, and heart failure, and gastrointestinal-related issues may include peptic ulcers, bleeding, liver dysfunction, cerebrovascular disorders, extrapyramidal symptoms, and severe neurological symptoms, so it is advised to consult a physician immediately if any symptoms appear. This medication has also been reported to cause various side effects such as drowsiness, dizziness, hallucinations, insomnia, nausea, vomiting, diarrhea, loss of appetite, headaches, fatigue, so if these symptoms become severe, notify medical personnel. This medication is not approved for other types of dementia or memory impairments other than Alzheimer-type dementia, and treatment should be conducted under the supervision of an experienced physician. Patients with heart conditions or electrolyte abnormalities may have an increased risk of cardiac arrhythmia and may require ECG monitoring while taking this medication. Care should be taken when driving or operating machinery as this medication may cause dizziness or fatigue. This medication is metabolized by certain liver metabolic enzymes, so there may be interactions with other medications, especially antifungals, antibiotics, antidepressants, and antiarrhythmics, requiring caution. Pregnant or nursing women are advised not to use this medication unless absolutely necessary and should consult with medical personnel beforehand. Safety in pediatric patients has not been established, hence it is not used in children. In cases of overdose, severe symptoms such as nausea, vomiting, bradycardia, hypotension, respiratory depression, and seizures may occur, requiring immediate treatment at a medical facility. This medication should be kept out of the reach of children, and transferring it to other containers is not advisable as it may compromise quality.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with fever, blisters, peeling skin, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory issues accompanied by cough + fever, jaundice (yellowing of skin or eyes), profound lethargy, sudden and severe headache, lightning-like headache, seizures, confusion, visual disturbances, paralysis, urination.

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headaches
• fatigue
• dizziness
• insomnia
• drowsiness
• muscle pain

This medication should be stored in an airtight container, preferably at room temperature between 1°C and 30°C. Storing it this way helps maintain the effectiveness of the medication.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets, 100 tablets/bottle