Medication info

Pentablue 5 Weeks

Prescription medicationInjections정맥
Ingredient · strength
Zinc Sulfate Hydrate›4.39mg / 1mLCupric Sulfate Hydrate›1.57mg / 1mLManganese Sulfate Hydrate›0.308mg / 1mLChromic Chloride Hydrate›20.5μg / 1mLSelenious Acid›32.7μg / 1mL
Manufacturer / importer
안국약품(주)
Appearance
A colorless or light blue transparent solution without odor packed in a colorless transparent vial as an injectable
Packaging
10 milliliters/vial [X10EA]
Approval status
Active

MFDS item code 201601788 · Notified 2016.04.05

Summary

Main use
Improvement of nutritional status by supplying trace elements (such as zinc, copper, etc.)
Who receives it
Adults · Children
Adult administration
Use according to physician's prescription, confirming plasma trace element levels as guidelines for dosage adjustment. Patients receiving metabolically stable non-oral nutrition: Zinc: 2.5 to 4 mg per day Copper: 0.5 to 1.5 mg per day Manganese: 0.15 to 0.8 mg per day Chromium: 10 to 15 µg per day Selenium: 20 to 40 µg per day Others: Acute burn patients: 4.5 to 6 mg per day Metabolically stable intestinal fluid loss patients: additionally 12
Child administration
Pediatric patients - Under 5 years old: Zinc: 100 µg per kg of body weight per day Copper: 20 µg per kg of body weight per day Manganese: 2 to 10 µg per kg of body weight per day Chromium: 0.14 to 0.20 µg per kg of body weight per day Selenium: 1 day

Ingredients

Manufacturer
안국약품(주)

Efficacy & effects

Improvement of nutritional status by supplying trace elements (such as zinc, copper, etc.)

View approved original text

Providing trace elements like zinc, copper, manganese, selenium, and chromium during total parenteral nutrition improves the patient's nutritional status comprehensively and helps maintain bodily functions. These trace elements play critical roles in enhancing immunity, wound healing, antioxidant actions, and metabolic regulation, and their deficiency can lead to various metabolic disorders and health problems. Therefore, adequately supplying necessary trace elements during total parenteral nutrition promotes patient recovery and helps prevent complications.

How it is given

Adult administration

Use according to physician's prescription, confirming plasma trace element levels as guidelines for dosage adjustment. Patients receiving metabolically stable non-oral nutrition: Zinc: 2.5 to 4 mg per day Copper: 0.5 to 1.5 mg per day Manganese: 0.15 to 0.8 mg per day Chromium: 10 to 15 µg per day Selenium: 20 to 40 µg per day Others: Acute burn patients: 4.5 to 6 mg per day Metabolically stable intestinal fluid loss patients: additionally 12

Child administration

Pediatric patients - Under 5 years old: Zinc: 100 µg per kg of body weight per day Copper: 20 µg per kg of body weight per day Manganese: 2 to 10 µg per kg of body weight per day Chromium: 0.14 to 0.20 µg per kg of body weight per day Selenium: 1 day

Precautions

This medication contains benzyl alcohol, which is associated with fatal respiratory symptoms in premature infants, and should not be administered to newborns and premature infants. Direct intravenous injection without dilution can cause phlebitis, so it must be diluted before use. This medication is a hypotonic solution; it should only be used in mixed injections, and should not be infused alone. If any toxic symptoms occur during administration, discontinue use immediately and inform medical personnel. Aluminum in non-oral nutritional solutions can be toxic to patients with reduced kidney function, especially in premature infants, so caution is necessary. Before injection, the patient's condition and metabolic requirements must be accurately assessed, and the blood levels of trace elements should be frequently monitored to adjust the dosage. Patients with impaired kidney function should be cautious as zinc can accumulate in the body. Patients with biliary obstruction should be careful as copper and manganese may accumulate in the body during administration. Chromium is primarily excreted through the kidneys, and diabetic patients should consider their blood sugar control status and the diabetes medications they are taking. Selenium dosage should be adjusted in patients with kidney and gastrointestinal dysfunction, and for transfusion patients, one must consider the effects of the transfusion. In pregnant women or women who could become pregnant, this medication should only be used if the benefits of treatment outweigh the risks. Excessive dosages may lead to toxicity symptoms of trace elements like zinc, copper, and selenium, so it is crucial to strictly adhere to the prescribed dosages, and consult with medical personnel immediately if symptoms occur. This medication must be used according to a physician's prescription, and when adding to non-oral nutritional solutions, it should be mixed under aseptic conditions. Before use, verify the solution for discoloration or particulate matter; if abnormalities exist, do not use it. Store in a sealed container to protect from air or moisture, and it is safe to keep at room temperature between 15 degrees and 30 degrees Celsius. Maintaining proper temperature and conditions will help preserve the medication's effectiveness and prevent deterioration.

Side effects and when to seek care immediately

Serious side effects

  • Hypotension
  • pulmonary edema
  • jaundice
  • decreased urine volume
  • vascular congestion
  • pulmonary hemorrhage and congestion
  • severe peripheral vascular collapse
  • coma

Mild side effects

  • Hyperhidrosis
  • decreased consciousness
  • blurred vision
  • tachycardia
  • hypothermia
  • diarrhea
  • vomiting
  • faintness
  • behavioral changes
  • progressive wasting syndrome
Show 11 more
  • glare
  • hair loss
  • nail weakness
  • dermatitis
  • tooth damage
  • gastrointestinal disturbances
  • irritability
  • depression
  • metallic taste
  • sweating
  • garlic smell during breathing

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a sealed container to protect it from air and moisture, and it is safe to keep at room temperature between 15 degrees and 30 degrees Celsius. Proper temperature and conditions will help maintain the medication's effectiveness and prevent deterioration.

Appearance and packaging

Appearance

A colorless or light blue transparent solution without odor packed in a colorless transparent vial as an injectable

Package unit

10 milliliters/vial [X10EA]

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.