Lipicure Tablet 10 mg (Atorvastatin Calcium Trihydrate)

Adult dosage

The recommended starting dose for treating hyperlipidemia is 10 mg of atorvastatin administered once daily. For patients needing greater LDL cholesterol reduction, treatment may begin at 20 mg or 40 mg once daily. The dosage should be individualized based on the treatment goals and response, in the range of 10 to 80 mg once daily. Lipid levels should be analyzed within 2-4 weeks after treatment initiation and/or dose adjustment to modify the dosage accordingly. The goal of treatment is to lower LDL cholesterol; therefore, it is recommended to use LDL cholesterol levels when evaluating treatment initiation and response. If LDL cholesterol levels are unavailable, total cholesterol levels may be used to monitor treatment response. For patients with homozygous familial hypercholesterolemia, the dosing regimen is 10 to 80 mg daily, often administered in conjunction with other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are not feasible. 2. Pediatric patients with heterozygous familial hypercholesterolemia (10-17 years) The recommended starting dose is 10 mg daily, and the recommended maximum dose is 20 mg daily (there is no clinical data pertaining to doses over 20 mg in this pediatric cohort). Dosages should be adjusted appropriately according to the recommended therapeutic goals for each patient. Adjustments should be made at intervals of 4 weeks or longer. ○ In patients with renal impairment: Renal disease does not affect plasma concentrations of atorvastatin or its LDL cholesterol-lowering effects; therefore, dosage adjustment is unnecessary. ○ In elderly patients: The efficacy and safety in patients aged 70 and older are similar to those in the general adult population.

Children's dosage

The recommended starting dose for pediatric patients (10-17 years) with heterozygous familial hypercholesterolemia is 10 mg once daily, with a maximum dose of 20 mg per day. The dosage should be appropriately titrated according to therapeutic goals.

This medication poses a risk of muscle problems; thus, discontinue use immediately and consult a doctor if symptoms such as muscle pain or weakness occur. It should not be administered to those with an allergy to this medication or those with liver diseases or muscular disorders. Pregnant or breastfeeding women should not take this medication, and women of childbearing age must use appropriate contraception during its use. Patients with impaired liver function should exercise special caution when using this medication and should have regular liver function tests. This medication may interact with other drugs, so patients taking certain antibiotics, antifungals, antivirals, immunosuppressants, etc., must inform their doctor or pharmacist and exercise caution. Elderly patients or patients with reduced kidney function are at higher risk for muscle damage, requiring closer monitoring during use. During treatment, if symptoms such as muscle pain, fatigue, or fever occur, medical staff should be notified immediately. Children, especially those under 10 years old, should not take this medication, while adolescents over 10 years should only take it under a specialist's guidance. In case of overdose, there is no specific antidote, so one should go to the hospital immediately for treatment based on symptoms. Store this medication out of reach of children and ensure it is kept in its original container for safety. During treatment, closely monitor for symptoms of muscle abnormalities and signs of liver dysfunction, and notify a doctor if any abnormal symptoms occur.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, peeling skin, pain in the oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough and fever, jaundice (skin or eyes turning yellow), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion of consciousness, visual disturbances, paralysis, urination

Mild side effects

• Weakness
• fatigue
• chest pain
• peripheral edema
• tiredness
• fever
• pharyngitis
• hyperglycemia
• hypoglycemia
• weight gain

This medication should be stored in a sealed container to protect it from air or moisture. It is best to maintain storage temperatures between 1 to 30 degrees Celsius.

Appearance

White oval film-coated tablet

Package unit

30 tablets, 100 tablets