Simvastatin/Ezetimibe Tablet 10/10

Adult dose

This medication is administered once daily in the evening, regardless of meals. The dosage range for patients with primary hypercholesterolemia is 10/10mg to 10/40mg daily, and the generally recommended initial dosage is 10/20mg daily. Patients who do not require much reduction in LDL cholesterol can start at 10/10mg daily. After starting this medication or adjusting the dosage, blood lipid levels should be checked at intervals of more than 4 weeks.

This drug is primarily used to lower blood cholesterol levels. However, serious muscle-related side effects such as myopathy or rhabdomyolysis may occur while taking this medication, so caution is advised. The risk may be higher when taken in high doses or in conjunction with certain other medications. This drug should not be administered to patients with poor liver function, pregnant women, or nursing mothers. Special monitoring is necessary when this drug is used in patients with liver dysfunction or a history of liver disease. If severe muscle weakness symptoms appear, consult a physician immediately and discontinue use of the drug. This drug can interact with several other medications, so it is essential to inform healthcare professionals of any other medications being taken. In particular, combining with certain antibiotics, antifungals, immunosuppressants, and some heart medications can increase the risk of muscle damage. If symptoms such as muscle pain, muscle weakness, or severe fatigue occur during use, notify a healthcare facility immediately. Use in the elderly or children requires caution, and for children, consultation with a specialist is advised before use. Additionally, this drug may affect blood glucose levels, so regular blood glucose testing is recommended for patients at risk of diabetes. Regular liver function tests and muscle-related examinations during treatment are safe. There is no specific antidote for overdose, so immediate medical attention is required for appropriate treatment. Finally, women who plan to become pregnant or are pregnant should not use this medication, and it should be discontinued immediately if pregnancy is confirmed.

Serious side effects

Hives, severe swelling (edema), rash, angioedema, mucocutaneous syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), polymorphic erythema, anaphylaxis, elevation of liver amino transferase levels, hepatitis, pancreatitis, thrombocytopenia, myopathy, rhabdomyolysis, acute renal failure, jaundice, liver failure, severe muscle weakness, oculomotor weakness, headache, altered consciousness, seizures, visual disturbances, paralysis, respiratory distress

Mild side effects

• Headache
• diarrhea
• influenza
• upper respiratory tract infection
• muscle pain
• limb pain
• fatigue
• abdominal pain
• nausea
• constipation

This drug should be stored in a tightly sealed container to prevent exposure to air and moisture. The appropriate storage temperature is room temperature between 1 and 30 degrees Celsius, and it is advisable to avoid excessively hot or cold locations.

Appearance

White to light yellow, double convex, rectangular tablet

Package unit

30 tablets (10 tablets PTP packaging x 3)