DuoRovan Tablets 10/10 mg (Ezetimibe (Unrefined), Rosuvastatin Calcium)

Adult dose

This medication is administered once a day, regardless of meals. The dosage range is between 10/5 mg and 10/20 mg per day. A starting dose of 10/5 mg once daily is recommended. If further reduction in LDL-cholesterol is necessary, the dosage can be adjusted. Blood lipid levels should be checked at intervals of more than 4 weeks after starting the treatment or adjusting the dosage, and the dose may be increased up to a maximum of 10/20 mg per day.

This medication can rarely cause rhabdomyolysis, which can lead to serious muscle damage, so patients should notify their doctor immediately if they experience muscle pain or weakness symptoms. In particular, if there are risk factors such as severe infections, hypotension, major surgery or trauma, severe metabolic disorders, it may be necessary to temporarily discontinue or stop the use of this medication. Individuals allergic to any ingredient of this medication, those with severe liver impairment, those with muscle diseases, those with severe renal impairment, and women who are pregnant or breastfeeding should not take this medication. Additionally, when taken with certain medications, the risk of side effects may increase; therefore, patients taking other medications should consult with healthcare professionals. This drug may affect liver function; thus, individuals with a history of liver disease or who consume alcohol heavily should undergo regular liver function tests, and treatment should be stopped immediately if symptoms of liver damage appear. Elderly patients or those at risk of myopathy need to be especially cautious when taking this medication and should be advised to undergo muscle-related testing before and during use. Women of childbearing potential should practice adequate contraception while taking this medication and should stop taking it immediately if pregnancy is confirmed. Safety in pediatric or adolescent patients has not been sufficiently established; therefore, it is not recommended for pediatric patients. In case of overdose, there is no specific antidote, so treatment should be symptomatic while monitoring liver function and muscle enzyme tests.

Serious side effects

Hives, swelling, chest tightness, difficulty breathing, cold sweat, paleness, high fever, severe rash, blisters, peeling skin, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough+fever, yellowing of skin or eyes (jaundice), severe lethargy, sudden and very severe headache, thunderclap headache, seizure, consciousness confusion, visual disturbances, paralysis, significantly decreased urine output.

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• muscle pain
• itching
• rash
• pruritus
• weakness

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, and should be kept at room temperature between 1 degree and 30 degrees Celsius. Storing it this way helps maintain the effectiveness and safety of the medication.

Appearance

White to almost white round film-coated tablets

Package unit

Alu-Alu - 30 tablets/box [(10 tablets/Alu-Alu×3)], Bottle - 30 tablets/bottle