Eshuba Tablets 10/5 mg (Ezetimibe, Rosuvastatin)

Adult dose

This medication is administered once daily, regardless of meals. An initial dose of 10/5 mg is recommended. The dosing range is 10/5 mg to 10/20 mg daily, with a maximum dose of 10/20 mg daily possible. After initiation or adjustment of the dose, blood lipid levels should be checked at least 4 weeks apart.

This medication carries a risk of muscle-related side effects; therefore, if severe muscle pain or weakness occurs, the doctor should be notified immediately. Especially in patients with serious infections, hypotension, significant surgery or trauma, severe metabolic or endocrine disorders, uncontrolled seizures, it may be necessary to temporarily discontinue or stop this medication. Patients allergic to any of the components of this medication, those with active liver disease, muscle disorders, severe kidney function impairment, women who are pregnant or breastfeeding should not take this medication. Additionally, caution is advised for those with a history or family history of certain muscle disorders, hypothyroidism, alcoholism, or those taking specific medications. This medication contains lactose; therefore, patients with genetic predispositions to lactose intolerance should avoid taking it. Patients with poor liver function or a history of alcoholism, the elderly, and those with impaired kidney function should use this medication cautiously. This medication may increase liver enzyme levels; therefore, liver function tests should be conducted before initiation, and regular monitoring of liver condition should continue during treatment. If any unusual liver symptoms or jaundice occur during treatment, administration should be stopped immediately. This medication may slightly raise blood sugar levels; hence, patients at risk for diabetes should regularly monitor their blood sugar. There may be interactions with other drugs; therefore, patients taking other medications should inform their doctor or pharmacist. Caution is particularly necessary when taken with anticoagulants, fibrates, certain antibiotics, and antifungals. This medication should not be taken by women who are pregnant or may become pregnant, and appropriate contraception should be used while taking it. It is also advised that breastfeeding women avoid this medication. Safety for children and adolescents has not been sufficiently established; therefore, it is not recommended. In cases of overdose, no specific antidote exists, and symptomatic treatment and supportive care are necessary while monitoring liver function and muscle status. This medication should be kept out of reach of children and should not be transferred to other containers.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blistering, skin shedding, pain in mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme fatigue, sudden and severe headache, thunderclap headache, seizures, confusion, vision changes, paralysis, reduced urine output.

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• nasopharyngitis
• fatigue
• itching
• rash
• muscle pain

This medication may be sensitive to air or moisture, so it should be stored in a tightly closed container. It is recommended to keep it at room temperature between 1 to 30 degrees Celsius, avoiding extreme heat or cold.

Appearance

White oval film-coated tablets

Package unit

30 tablets (10 tablets PTP x 3), 30 tablets/bottle, 100 tablets/bottle