Amlodipine Tablet (Amlodipine Besylate)

Adult dose

Adults: 5 mg of amlodipine is administered orally once daily, and may be increased up to a maximum of 10 mg daily based on patient response. Adjust dosage appropriately based on age and symptoms.

This medication is a dihydropyridine calcium channel blocker that lowers blood pressure and reduces cardiac burden. It should not be used in patients with hypersensitivity, in breastfeeding individuals, those with severe liver dysfunction, patients with aortic stenosis, or those in shock. Patients with severe hypotension, those requiring dialysis due to renal failure, elderly patients, and pregnant or potentially pregnant women should use this medication with caution. Common side effects include flushing, fatigue, swelling, palpitations, dizziness, headache, drowsiness, abdominal pain, and nausea. Rarely, various side effects such as weakness, hypotension, vasculitis, neurological symptoms, erectile dysfunction, dry mouth, hyperglycemia, joint pain, blood disorders, insomnia, skin rashes, etc., may occur. In patients with heart failure or impaired liver function, the effects and side effects of this drug should be carefully monitored. Even if stopped, the blood pressure-lowering effect fades gradually; hence dosage and intervals should be monitored if used in conjunction with other antihypertensive medications. This medication may not be suitable for situations requiring rapid blood pressure reduction in emergencies. It is known not to significantly affect driving or machinery operation abilities. Interactions may occur when taken with certain medications, especially with grapefruit juice, specific antibiotics, antihypertensive drugs, and immunosuppressants, hence caution is necessary. During pregnancy, due to safety not established, it should be used only in special cases, and breastfeeding should be discontinued while taking this drug. For pediatric patients, it should only be used in those aged 6 years and older, as safety and efficacy are not established for those under 6 years. Elderly patients generally tolerate the standard doses well, but careful observation is required. In case of overdose, severe hypotension and reflex tachycardia may occur, requiring immediate medical assistance, and gastric lavage or administration of activated charcoal may be helpful if necessary. This drug is not removed by hemodialysis, so proactive cardiovascular support treatment is necessary in case of overdose.

Serious side effects

• Hives, angioedema, erythema multiforme → severe allergic reaction.
• Toxic epidermal necrolysis, skin peeling → severe skin reaction.
• Difficulty breathing, respiratory difficulties → respiratory problems.
• Jaundice, yellowing of skin or eyes → liver abnormalities (jaundice).

Mild side effects

• Flushing
• fatigue
• swelling
• palpitations
• dizziness
• headache
• drowsiness
• abdominal pain
• nausea
• weakness

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, maintaining a storage temperature between 1°C and 30°C at room temperature. Proper storage will help to preserve the drug's effectiveness.

Appearance

White octagonal tablet

Package unit

30 tablets/bottle, 500 tablets/bottle