Nexprazole 20mg (Esomeprazole Magnesium Trihydrate)

Adult dosage

The medication should be swallowed whole with liquids like water and should not be chewed or crushed. 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive esophagitis: 40 mg once daily for 4 weeks. - If symptoms continue or there is no improvement, continue for an additional 4 weeks. - Maintenance therapy to prevent recurrence in patients with esophagitis: 20 mg once daily. - Treatment of symptoms associated with gastroesophageal reflux disease in the absence of esophagitis.

Children's dosage

For adolescents aged 12 years and older: 1) Gastroesophageal reflux disease (GERD) - Treatment of erosive esophagitis: 40 mg once daily for 4 weeks. - If not improved or symptoms persist, an additional 4 weeks of treatment.

This medication should not be administered to certain patients. Patients who have allergy or hypersensitivity to this drug or its components, or to benzimidazole derivatives, should not use it. Moreover, patients with hypersensitivity to antibiotics amoxicillin or clarithromycin should not be administered when used in combination for the eradication of Helicobacter pylori. Patients taking specific heart medications or with a history of myocardial infarction, as well as nursing women, should not use this medication. This medication may cause various side effects. Gastrointestinal symptoms such as headache, abdominal pain, diarrhea, nausea, and vomiting may occur frequently, and sometimes neurological symptoms like dizziness and insomnia are also reported. Rarely, serious side effects such as decreased blood cell count, hypersensitivity reactions, liver function anomalies, skin rashes, and myalgia may occur, requiring immediate consultation with a physician if symptoms are severe or persistent. With long-term use, electrolyte disturbances such as hypomagnesemia may arise, necessitating regular testing. This medication inhibits gastric acid secretion, thereby lowering gastric acidity, which can alter the normal bacterial balance in the gastrointestinal tract, potentially increasing the risk of certain infections. Additionally, long-term or high-dose usage may elevate the risk of fractures, so caution is advised in patients with a risk of osteoporosis. This medication has a high potential for interaction with other drugs. Particularly, when used in combination with antibiotics, antivirals, anticoagulants, antidepressants, etc., the effects of the drugs may change, making it imperative to inform your doctor or pharmacist about medications currently being taken. Moreover, co-administration with certain drugs may alter the plasma concentration of this medication or other medications, necessitating caution. Due to limited data on safety during pregnancy, pregnant women should use this medication cautiously and after consulting a physician. Nursing women should avoid this medication since it may be excreted in breast milk. There are no specific antidotes for overdose, so symptomatic treatment and general management are necessary; it should be stored out of reach of children to ensure safety. Additionally, transferring to another container is advised against due to the risk of quality degradation or misuse.

Serious side effects

Urticaria, angioedema, anaphylaxis, shock, severe edema, hypomagnesemia, hypocalcemia, hypokalemia, hepatitis, liver failure, jaundice, Stevens-Johnson syndrome, toxic epidermal necrolysis, mucosal membrane syndrome, acute generalized exanthematous pustulosis, eosinophilia, and systemic symptoms associated with drug reaction (DRESS syndrome), interstitial nephritis, severe allergic reactions, severe skin adverse reactions, respiratory distress, difficulty in breathing.

Mild side effects

Headache, insomnia, anxiety, mental confusion, depression, aggression, hallucinations, dizziness, altered perception, drowsiness, taste disturbances, blurred vision, bronchospasm, abdominal pain, constipation, diarrhea, abdominal distension, nausea, vomiting, dry mouth, stomatitis, gastrointestinal candidiasis, pancreatitis, elevated liver enzymes, dermatitis, itching, rashes, hair loss, photosensitivity, fractures, arthralgia, myalgia, muscle weakness, asthenia, increased sweating, Clostridium difficile-associated diarrhea.

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius. Proper storage will safeguard the medication's efficacy.

Appearance

Pink round film-coated tablets

Package unit

28 tablets (14 tablets / Alu-Alu X 2)