Pencain Cream

Adult dosage

Apply approximately 1.5-2g/10㎠ to the skin for 1-5 hours, covering it with an occlusive dressing. During needle insertion, apply approximately 2g for a minimum of 1 hour to a maximum of 5 hours. For superficial surgical procedures, apply approximately 1.5-2g/10㎠ for 1 hour. For superficial large surgical procedures, apply approximately 1.5-2g/10㎠ for a minimum of 2 hours to a maximum of 5 hours. During the removal of genital mucosal condylomas, apply approximately 10g for 5-10 minutes.

Children's dosage

For infants aged 3 months to 12 months, a total amount of 2g should not exceed an application area of 16㎠.

This drug is used as a local anesthetic and may cause a rare blood disorder known as methemoglobinemia. This condition reduces the oxygen-carrying capacity of the blood, possibly causing the skin to take on a bluish hue or, in severe cases, leading to problems in the central nervous system and heart. Patients with glucose-6-phosphate dehydrogenase deficiency, congenital methemoglobinemia, heart or lung diseases, infants under 6 months of age, and those using specific oxidizing agents should exercise extra caution. While using this drug, one must closely monitor for symptoms and signs of methemoglobinemia, and if symptoms appear, usage must be immediately stopped and treatment sought. Additionally, this drug should not be used on individuals with hypersensitivity to it, in areas with wounds or dermatitis, in infants under 3 months, and in infants under 12 months or premature infants who are taking specific medications. Anemia, frail patients, elderly individuals, and those with liver diseases should use with caution, and precaution is necessary if allergic to any of the components of this drug. When applied to the skin, temporary pallor, redness, swelling, burning sensation, itching, local sensitization reactions, numbness, and skin irritation may occur, and rarely, severe allergic reactions or anaphylactic shock may happen. It may cause irritation if it comes in contact with the eyes, so it should not be applied around the eyes; if contact occurs, it should be rinsed immediately with clean water. The toxicity may be increased when this drug is used with other local anesthetics or certain medications, so caution is advised during concomitant use. Pregnant or breastfeeding women should use it cautiously after consulting with a doctor, and it should be used restrictively in children, especially infants under 3 months. Overdosage may lead to symptoms of methemoglobinemia or adverse effects on the central nervous system and cardiovascular system, therefore, the dosage must be strictly followed, and any abnormal symptoms should be reported to healthcare professionals immediately. Finally, it is advisable to avoid prolonged or high-dose usage of this drug, and if any adverse reactions or suspicious symptoms occur during use, immediate consultation with a specialist should be sought.

Serious side effects

• Methemoglobinemia
• allergic reactions
• anaphylactic shock
• seizures
• coma
• arrhythmia

Mild side effects

• Transient local reactions of pallor
• redness
• swelling
• mild initial burning sensation
• itching
• localized sensitization reactions
• tingling
• skin irritation
• corneal irritation

This drug should be stored in a tightly closed container to prevent exposure to air or moisture, and it is safe to store at room temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication for a longer period.

Appearance

White cream formulation

Package unit

5g/tube