Ezetimibe/Simvastatin 10/20 mg Tablet

Adult dose

This medication is administered once daily in the evening, regardless of meals. For patients with primary hypercholesterolemia, the dosage range is from 10/10 mg to 10/40 mg daily, with the generally recommended initial dose being 10/20 mg daily. Patients for whom a reduction in LDL-cholesterol is less critical may start at 10/10 mg daily. In patients with homozygous familial hypercholesterolemia, the recommended dose is 10/40 mg daily, taken once in the evening.

This medication is used to lower blood cholesterol levels. However, caution is needed as this medication can cause muscle issues. Especially if muscle pain or weakness occurs, inform the physician immediately. Additionally, this medication may affect liver function, so it should not be used in cases of liver disease or abnormal liver function tests. Women who are pregnant or breastfeeding should not take this medication, and women planning to become pregnant must consult a doctor. This medication may increase the risk of muscle disease when taken with specific antifungals, antibiotics, or antivirals; therefore, inform your doctor if you are taking these medications. Elderly patients or those with impaired kidney function also need to be cautious when taking this medication. During treatment, any unusual symptoms such as muscle pain, weakness, or darkening of urine should be reported to healthcare personnel immediately. This medication should not be administered to patients with certain genetic diseases. While taking this medication, it is advisable to perform regular blood tests to monitor liver function and muscle condition. It is safe to avoid foods or drinks that inhibit the CYP3A4 enzyme, such as grapefruit juice, when taking this medication.

Serious side effects

Urticaria, angioedema, anaphylaxis, rash, mucocutaneous syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), erythema multiforme, drug reaction with eosinophilia and systemic symptoms (DRESS), severe edema, liver abnormalities (including hepatitis and jaundice), severe rash with high fever and skin peeling, severe allergic reactions, difficulty breathing, dyspnea, asthma attacks, severe skin reactions, thrombocytopenia,

Mild side effects

Headache, diarrhea, influenza, upper respiratory tract infection, myalgia, limb pain, fatigue, nausea, abdominal pain, constipation, dyspepsia, flatulence, gastritis, atrophic gastritis, mucus in stool, irritable bowel syndrome, sore throat, nocturia, hematuria, pruritus, alopecia, asthenia, paresthesia, dizziness, insomnia, nausea, vomiting, chest discomfort, increased serum creatine phosphokinase (CPK), weight loss

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. It is recommended to keep the storage temperature between 1 and 30 degrees Celsius at room temperature to safely maintain the efficacy of the medication for a longer period.

Appearance

White to off-white, double-convex, rectangular tablets

Package unit

30 tablets