GCBibon Injection (Sodium Bicarbonate)

Adult administration

As sodium bicarbonate, administer 1–5g (12–60mEq) via intravenous injection per dose. The usual dosage for acidosis is calculated generally by the following formula and administered intravenously. Required Amount (mEq) = Base Deficit (mEq/L) × 0.2 × Weight (kg) Adjust based on age and symptoms as appropriate.

This medication should be carefully cut to avoid glass fragments when using ampoules. Extra caution is especially needed when administering to children or the elderly. This medication should not be administered to patients with renal disease, metabolic or hematologic alkalosis, hypertension, and those with certain inflammatory conditions. Also, patients with edema, congestive heart failure, hypocalcemia, hypernatremia, or respiratory distress should not use this medication. Caution is required when administering to patients with toxemia of pregnancy, hypocalcemia, hypokalemia, neonates, cardiac arrest patients, oliguria, or anuria. In cases of overdose, symptoms may include electrolyte imbalance, delayed blood coagulation, muscle cramps, respiratory issues, excessive excitation, dry mouth, arrhythmias, and other symptoms, necessitating an immediate cessation of administration and appropriate action. Rarely, side effects such as lip numbness or sensory abnormalities, inflammation or necrosis at the injection site, fever, malaise, anemia, nausea, and bradycardia may occur. When administering the drug intravenously, it is essential to check the acidity and carbon dioxide level in the blood to prevent adverse effects from overdose, and adequate ventilation is necessary during cardiopulmonary resuscitation. Interactions may occur with other drugs, so caution should be exercised when used alongside corticosteroids, specific diuretics, or potassium supplements. If pregnant or breastfeeding, the use of this drug may pose risks to the fetus or baby, so consultation with a doctor is crucial. It is advisable to suspend breastfeeding while on this medication. When administered to neonates, the drug should be diluted and given slowly to minimize the risk of intracranial hemorrhage. In the elderly, physical functions may decline, requiring a slower rate of administration and dose adjustment. In case of overdose, administration of this drug should be halted, and appropriate treatment should be provided according to the level of alkalosis, including possible use of acidifiers. When preparing the medication, it should not be mixed with other injectables or used alongside calcium-containing preparations. Also, it should be used immediately after opening, with any remaining medication discarded. It is essential to confirm that the intravenous needle is properly positioned when administering, taking care to prevent extravasation. If vascular pain occurs, the injection site should be changed or administration stopped.

Serious side effects

Pulmonary edema, seizures

Mild side effects

• Prolonged coagulation time
• cramps
• rigidity
• compensatory hyperventilation
• excessive excitation
• dry mouth
• xerostomia
• arrhythmias
• emotional or mental changes
• lip numbness

This medication may be sensitive to light, so it should be stored in a container that does not allow light exposure. Additionally, it is best to store the medication at a temperature between 1 to 30 degrees Celsius. This method of storage helps maintain the efficacy of the drug for longer.

Appearance

A brown glass ampoule containing a colorless clear liquid.

Package unit

50 ampoules/box [(2mL/ampoule)]