Esomel 40 mg (Esomeprazole Magnesium Trihydrate)

Adult dosage

This medication should be swallowed with liquid, such as water, and should not be chewed or crushed. 1. Gastroesophageal reflux disease (GERD) - Treatment of erosive esophagitis: 40 mg once daily for 4 weeks; if symptoms persist, an additional 4 weeks of treatment. - Maintenance therapy to prevent recurrence of esophagitis: 20 mg once daily. - For treatment of gastroesophageal reflux disease symptoms without esophagitis: 20 mg once daily for 4 weeks; if symptoms do not improve, further medical advice is necessary.

Children's dosage

Adolescents aged 12 and above: - For the treatment of erosive esophagitis: 40 mg once daily for 4 weeks; if symptoms persist, an additional 4 weeks of treatment. - For the treatment of gastroesophageal reflux disease symptoms without esophagitis: 20 mg once daily.

This medication should not be administered to certain patients. It should not be used in individuals with known allergies or hypersensitivity to this drug, its ingredients, or benzimidazole derivatives. Patients who have allergies to antibiotics like amoxicillin or clarithromycin, when used to eradicate Helicobacter pylori, should also avoid this medication. Patients taking specific heart-related medications or antiviral agents, nursing women, and those with a history of myocardial infarction should also refrain from using this drug. This medication can cause various side effects; therefore, caution is needed. Gastrointestinal symptoms like headache, abdominal pain, diarrhea, nausea, and vomiting can occur frequently. Rarely, various symptoms such as blood abnormalities, hypersensitivity reactions, hypomagnesemia, mental confusion, skin rashes, and muscle pain may arise. Particularly with prolonged use, magnesium deficiency may worsen, so periodic checks of magnesium levels in the blood are necessary. If severe skin reactions or muscle-related symptoms occur, immediate consultation with healthcare professionals is necessary. Due to its acid-suppressing action, the risk of bacterial infections in the gastrointestinal tract may slightly increase with prolonged use. Furthermore, for patients with osteoporosis or a high risk of fractures, long-term use may increase the risk of fractures, which may require bone density testing. This medication has many drug interactions; therefore, care should be taken with other medications being taken. In particular, when used with anticoagulants, anticonvulsants, certain antibiotics, antivirals, and immunosuppressants, there may be an increased risk of changes in drug concentrations or side effects, so consultation with a doctor or pharmacist is essential. When using this drug during pregnancy, safety data is limited, so caution is warranted; during breastfeeding, it is recommended to avoid use as the excretion of this drug into breast milk is unknown. In case of overdose, there is no specific antidote, so treatment should be symptomatic, and general supportive care is necessary; it should be stored out of reach of children. Additionally, it is safer to keep it in its original packaging without transferring it to another container.

Serious side effects

Urticaria, angioedema, anaphylactic reaction/shock, hypomagnesemia, mental confusion, anxiety, fever, jaundice, hepatitis, liver failure, encephalopathy, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), muscle weakness, interstitial nephritis, Clostridium difficile-associated diarrhea, severe skin reactions.

Mild side effects

• Headache
• dizziness
• paresthesia
• drowsiness
• taste disturbances
• blurred vision
• bronchospasm
• abdominal pain
• constipation
• diarrhea

This medicine must be stored in a tightly closed container to protect it from air and moisture. The recommended storage temperature is between 1°C to 30°C at room temperature.

Appearance

Pink rectangular film-coated tablets

Package unit

28 tablets per box [(14 tablets/Alu-Alu x 2)]