Oxychloroquine Tablet 300 mg (Hydroxychloroquine Sulfate)

Adult dose

1. Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, photosensitive skin disorders Adults - The initial dose is 200～400mg per day. If administering 400mg, give it in divided doses. Once an effect is observed, reduce the dose to 200mg per day; if the effect is inadequate, increase it to 400mg per day. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day. * It may take several weeks for this medicine to take effect, whereas adverse reactions may occur sooner. * If there is no improvement in symptoms after 6 months of treatment for rheumatoid arthritis, juvenile rheumatoid arthritis, discoid or systemic lupus erythematosus, discontinue the medicine. * When used for photosensitive disorders, administer only during periods of substantial exposure. 2. Malaria 1) Treatment Adults - For treatment of acute disease, administer 800mg initially, then 400mg every 6∼8 hours for 3 additional doses, for a total of 2g over 2 days. For treatment of acute disease caused by P. falciparum or P. vivax, a single dose of 800mg may also be administered. 2) Prevention Adults - Administer 6mg/kg once weekly (usually 400mg once weekly), starting 2 weeks before exposure.

Child dose

1. Rheumatoid arthritis, juvenile rheumatoid arthritis, discoid and systemic lupus erythematosus, photosensitive skin disorders Children - The usual average daily dose is 200∼400mg. The maintenance dose should be set at the minimum effective dose and must not exceed 6.5mg/kg/day or the adult dose, regardless of body weight. 2. Malaria 1) Treatment Children - Administer 10mg/kg as chloroquine initially, then 5mg/kg every 6-8 hours for 3 additional doses, for a total of 25mg/kg over 2 days. However, the adult dose must not be exceeded. 2) Prevention Children - Administer 6mg/kg once weekly, starting 2 weeks before exposure. For children weighing 30∼40kg or less, even 1 tablet (200mg) exceeds the appropriate dose; therefore, administration is not recommended.

This medication should not be administered to certain patients. For example, individuals who are allergic to this drug or similar compounds, those with existing eye problems, those taking drugs that may cause visual impairment, children, and pregnant or breastfeeding women should not use this medication. Additionally, there are patients who should use it with caution. Patients with allergies to quinine, psoriasis, liver or kidney disease, severe gastrointestinal disorders, severe neurological disorders, blood disorders, or porphyria should be cautious when using this drug. This medication may cause various adverse reactions. It can affect the eyes, leading to blurred vision or retinal damage, as well as skin rashes or hair loss, gastrointestinal disturbances, central nervous system symptoms, muscle weakness, blood abnormalities, cardiac arrhythmias, liver damage, psychiatric symptoms, and more. While taking this medication, it is necessary to undergo regular ophthalmologic examinations, and if visual impairment occurs, the medication should be discontinued immediately and medical attention sought. Patients with poor liver or kidney function should be monitored more closely to adjust drug concentrations, and regular blood tests should also be conducted. This medication can interact with other drugs, so if taking other medications, it is important to inform your doctor or pharmacist. It is safer for pregnant or breastfeeding women not to use this medication, and those planning to become pregnant or currently nursing should consult a physician. Serious side effects can occur in cases of overdose, so dosing should be strictly adhered to, and immediate emergency treatment should be sought if an overdose is suspected. Lastly, this medication should be stored out of reach of children, and transferring it to another container may adversely affect its quality, so caution is advised.

Visual disturbances, retinal abnormalities, decreased sensitivity of the cornea, corneal opacity, retinopathy, visual impairment, changes in pigmentation, scotoma, halos, glare, skin rash, hives, changes in pigmentation of the skin and mucous membranes, hair discoloration, alopecia, vesicular rash, erythema multiforme, Stevens-Johnson syndrome, photosensitivity reactions, exfoliative dermatitis, Sweet's syndrome, severe cutaneous adverse reactions, acute generalized exanthematous pustulosis, DRESS syndrome, nausea, diarrhea, loss of appetite, abdominal pain, upper abdominal cramps, vomiting, weakness, fatigue, sensorineural hearing loss, hallucinations, headache, drowsiness, restricted neuroexcitability, mood changes, nightmares, tinnitus, dizziness, hearing loss, unstable mood changes, psychosis, seizures, skeletal muscle myopathy, neuromuscular disorders, perceptual changes, decreased deep tendon reflexes, abnormal nerve conduction, aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, bone marrow suppression, QT prolongation, torsades de pointes, ventricular tachycardia, ventricular tachycardia, cardiomyopathy, biventricular hypertrophy, conduction disturbances, abnormal liver function test results, fulminant hepatic failure, hepatocellular damage, cholestatic liver injury, acute hepatitis, mixed hepatocellular/cholestatic liver injury, fulminant hepatic failure, depression, anxiety, agitation, confusion, delusions, mania, sleep disorders, weight loss, lethargy

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is recommended to maintain a storage temperature between 1 degree and 30 degrees Celsius. Proper storage will help retain the medication's effectiveness over time.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle