Ranitramine Tablets

Adult dose

Typically taken orally, 1 tablet twice a day, regardless of mealtimes, in the morning and before bedtime. 1) Gastric and duodenal ulcers Take 1 tablet twice daily or 2 tablets once daily before bedtime. Especially for duodenal ulcer patients, taking 2 tablets twice a day in the morning and before bedtime increases the treatment rate. The dosage remains the same for ulcers caused by NSAID administration or long-term use. Usually, diseases due to NSAID administration within 4 weeks typically heal within 8 weeks, but healing time may be extended for certain patients.

This drug should not be used in patients with poor kidney function or those undergoing dialysis. Additionally, it should not be administered to patients who have had allergic reactions to this drug or its ingredients. Care should be taken in patients with a history of acute porphyria, as this drug may provoke seizures. It is also considered safe not to administer this drug to patients who have had upper gastrointestinal surgery, pregnant women, women of childbearing potential, as well as premature infants and neonates. Patients on a potassium-restricted diet should also avoid using this medication. Patients with impaired liver function, those with a history of drug allergies, and the elderly should use this drug with caution. Patients with a history of kidney impairment and those taking anti-inflammatory pain relief medications, especially the elderly or patients with a history of peptic ulcers, should be regularly monitored. This drug may mask symptoms of gastric cancer, so patients with gastric ulcers or middle-aged patients recently experiencing new dyspeptic symptoms should have malignancy checked before treatment. Patients with gastric or duodenal ulcers with Helicobacter pylori infection require eradication therapy. Caution is advised when using this medication in severely ill patients, patients with hypophosphatemia, and those with dysphagia. Symptoms such as allergic reactions, blood anomalies, liver dysfunction, arrhythmias, gastrointestinal disturbances, or neuropsychiatric symptoms can occur; thus, if any symptoms arise, immediate consultation with medical professionals is required. Long-term use should be avoided, and if therapeutic effects are absent, it is better to switch to another medication. Dizziness or drowsiness may occur, hence driving or operating dangerous machinery is not recommended. There may be drug interactions, so patients taking anticoagulants, certain antibiotics, anticonvulsants, etc., should notify their healthcare providers. It is safe not to take this medication during pregnancy or breastfeeding. Safety in children has not been established, so it is preferable not to use it in pediatric patients. In cases of overdose, emergency measures such as vomiting or gastric lavage may be needed, thus prompt hospital visit is essential. This drug reduces gastric acid secretion and can promote bacterial growth in the stomach; therefore, additional caution, including ophthalmic examination, is required for long-term use.

Serious side effects

Shock (anaphylactic shock), hives, angioedema, bronchospasm, severe allergic reactions, agranulocytosis, pancytopenia, bone marrow suppression, aplastic anemia, acquired immune hemolytic anemia, jaundice or non-jaundice hepatitis, liver dysfunction, arrhythmias (tachycardia, bradycardia, heart block, premature ventricular contractions), vasculitis, severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), acute interstitial nephritis

Mild side effects

• Skin rash
• angioedema
• fever
• hypotension
• chest pain
• granulocytopenia
• leukopenia
• thrombocytopenia
• elevated serum enzyme levels
• nausea

This medication can be sensitive to air or humidity, so it should be stored in a tightly sealed container. Additionally, avoid storing it in places that are too hot or too cold; it is best to keep it at room temperature between 1°C and 30°C.

Appearance

Greenish rectangular film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle