Jardiance Duo Tablet 12.5/500 mg

Adult dose

The recommended dosage for this medication is 1 tablet once daily, twice daily. The dosage should be determined considering the current therapy, efficacy, and tolerability of each patient, while not exceeding the maximum daily recommended doses of empagliflozin 25 mg and metformin 2000 mg. - For patients who are unable to achieve adequate blood glucose control with metformin alone or other drugs including insulin, the recommended dosage is empagliflozin 5 mg once daily, twice daily.

This medication aids in blood glucose control but could rarely cause serious side effects like lactic acidosis, requiring caution. When taken with other diabetes medications, there is a risk of hypoglycemia, so blood glucose levels should be closely monitored. It should not be administered to patients with moderate to severe renal impairment, acute kidney issues, severe infections, heart failure, or acute myocardial infarction. Medication should be discontinued before and after tests using iodine-containing contrast agents, resuming only when kidney function is confirmed to be normal. It is not recommended for use in pregnant or breastfeeding women, nor in children under 18 years of age. During treatment, attention should be paid to signs of fluid loss or dehydration, liver dysfunction, hypoglycemia symptoms, urinary tract infections, and genital infections. Elderly patients or those with reduced kidney function should have regular kidney function tests and may require dose adjustments when used with insulin or sulfonylurea due to hypoglycemia risk. Moreover, this medication may reduce vitamin B12 levels, so monitoring vitamin B12 status during prolonged use is advised. In cases of overdose, the risk of lactic acidosis is present, requiring immediate notification to healthcare providers, with treatment potentially involving dialysis. Alcohol consumption should be avoided during treatment, and medication may need to be discontinued based on symptoms. Finally, if symptoms such as fever, pain in the genitals or perineum, redness, or swelling occur during treatment, immediate consultation with healthcare providers is necessary, as this can indicate a serious infection needing prompt treatment.

Serious side effects

Hives, angioedema, ketoacidosis, lactic acidosis, urosepsis, pyelonephritis, necrotizing fasciitis of the perineum, severe swelling, chest tightening, difficulty breathing, pallor, severe allergic reactions, high fever with severe rash, blisters, skin peeling, pain in oral/ocular mucosa, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, breathing irregularities accompanied by cough and fever, yellowing of skin or eyes, jaundice

Mild side effects

• Hypoglycemia
• urinary tract infections
• genital infections
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. The storage temperature should be maintained between 1 and 30 degrees Celsius at room temperature. This will ensure that the chemical composition remains stable and safe for use.

Appearance

Light brownish-purple, oval-shaped, biconvex film-coated tablet

Package unit

60 tablets/box [10 tablets/PTP × 6 packs]