Guardmet Tablet 100/850 mg (Anagliptin, Metformin)

Adult dose

The dosage of this medication should be adjusted based on efficacy and tolerance, while not exceeding the maximum recommended daily doses of anagliptin 200 mg and metformin 2000 mg for each component. The initial dose of this medication should be determined according to the patient's current treatment regimen. This medication should be taken twice daily with meals, and dosage increases should be gradual. 1. Initial dosages in cases where sufficient blood sugar control cannot be achieved with metformin monotherapy: the initial dosage of this medication should consist of 100 mg of anagliptin taken twice daily (total daily dosage 200 mg) and the previously prescribed dose of metformin, along with one tablet of this medication at 100/500 mg or 100/850 mg or 100/1000 mg taken twice daily. 2. Switching from combined therapy of anagliptin and metformin: when transitioning from combined therapy of anagliptin and metformin to this medication, it can be initiated at the previous dosages of anagliptin and metformin.

This medication helps in controlling blood sugar levels. However, it can rarely cause a serious condition called lactic acidosis, so caution is required. It should not be administered to patients with poor kidney function, weak heart function, or those with acute infections or severe trauma. Furthermore, patients scheduled for surgery should discontinue this medication 48 hours prior to surgery and can resume only after confirming normal kidney function. This medication may cause symptoms of hypoglycemia when taken with insulin or other diabetes medications, so blood sugar levels should be closely monitored during treatment. If sudden severe abdominal pain or vomiting occurs while taking this medication, it may indicate acute pancreatitis, and immediate consultation with a physician is necessary. Regular monitoring of liver and kidney functions should be conducted during the use of this medication to ensure there are no abnormalities, especially for elderly patients or those with impaired kidney function. Alcohol consumption may increase the risk of lactic acidosis, so it is advisable to avoid alcohol while taking this medication. Pregnant or breastfeeding women should not use this medication, and those planning to become pregnant should also avoid it. Some patients may experience side effects such as constipation, diarrhea, dizziness, and headache; if any abnormal symptoms persist, consultation with a medical professional is recommended. Moreover, this medication may lower vitamin B12 levels, so regular blood tests are recommended. In case of overdose, seek medical attention immediately for appropriate treatment. Finally, the safety and efficacy of this medication have not been established in children, so it is advisable not to use it.

Serious side effects

Severe lactic acidosis, severe hypoglycemia, acute pancreatitis, bullous pemphigoid (blisters, erosion), vesicular bullous pemphigoid, severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor), severe skin adverse reactions (severe rash with high fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes), respiratory issues (shortness of breath or difficulty breathing, asthma attack, respiratory irregularities with coughing and fever), liver

Mild side effects

• Constipation
• mild hypoglycemia
• positive fecal occult blood
• diarrhea
• gastritis
• abdominal distension
• abdominal pain
• abdominal discomfort
• increased serum amylase
• nausea

This medication should be stored in a tightly closed container, protected from air and moisture, and kept at a temperature between 1 to 30 degrees Celsius. Proper storage will maintain the medication's effectiveness and prevent degradation.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets (10 tablets/PTP pack × 3), 60 tablets/bottle