Esomeprazole Magnesium Trihydrate 40 mg Tablets

Adult dosage

This medication should be swallowed with liquids such as water and should not be chewed or crushed. 1. Gastroesophageal reflux disease (GERD) - Treatment of erosive esophagitis: 1 dose of 40 mg once daily for 4 weeks. If symptoms persist or do not improve, an additional 4 weeks of treatment may be needed. - Long-term maintenance therapy for esophagitis relapse prevention: 1 dose of 20 mg once daily. - Treatment of symptoms in gastroesophageal reflux disease without esophagitis: · 1 dose of 20 mg once daily. If symptoms are not controlled after 4 weeks, further medical attention may be needed. · Once symptoms are relieved, for any ongoing symptoms, administer 1 dose of 20 mg once daily. · In adults, 1 dose of 20 mg may be given as needed. For patients at high risk of gastric and duodenal ulcers due to NSAID use, it is not recommended to give doses as needed for continuous symptom control. 2) Antibiotic combination therapy for eradication of Helicobacter pylori Administer 20 mg of this medication in combination with 1 g of amoxicillin and 500 mg of clarithromycin twice daily for 7 days. 3) Short-term therapy for upper gastrointestinal symptoms (pain, discomfort, burning sensation) related to NSAID (COX-2 non-selective, selective) administration - 1 dose of 20 mg once daily. If symptoms are not controlled after 4 weeks, further medical attention may be necessary; clinical trials exceeding 4 weeks have not been conducted. 4) Patients requiring continued NSAID administration - Treatment of gastric ulcers associated with NSAID use: 1 dose of 20 mg once daily for 4 to 8 weeks. - Prevention of gastric and duodenal ulcers associated with NSAID use: 1 dose of 20 mg once daily. 5) Treatment of Zollinger-Ellison syndrome The recommended initial dose is 40 mg twice a day. Subsequent dosages should be adjusted based on individual patient needs, continuing treatment while clinical symptoms are present. Most patients can be managed on a dosage between 80 mg and 160 mg per day. Dosages over 80 mg per day should be divided into two doses. 6) Maintenance therapy following IV induction for prevention of rebleeding from gastric or duodenal ulcers Administer 40 mg once daily for 4 weeks after IV induction for prevention of rebleeding from gastric or duodenal ulcers.

Children's dosage

For adolescents over 12 years old, the dosage is the same as that for adults: 1 dose of 40 mg once a day for 4 weeks. If there is no esophagitis, 1 dose of 20 mg once a day for 4 weeks, and dosage adjustments may be required based on symptom relief.

This medication should not be administered to certain patients. For example, patients with allergies to this drug or its constituents, those who have experienced allergic reactions in the past, those allergic to certain antibiotics, and those currently taking specific heart medications should not use this drug. Additionally, this drug should not be administered to breastfeeding women and patients with a history of myocardial infarction. Caution is needed when taking this medication as various adverse reactions may occur. Gastrointestinal symptoms such as headaches, abdominal pain, diarrhea, nausea, and vomiting have been reported, as well as skin rashes, itching, and, rarely, severe allergic reactions or blood abnormalities. Long-term use may lead to decreased magnesium levels, potentially causing muscle cramps or cardiac issues, necessitating regular blood tests. Especially in cases of extended use beyond one year, there may be an increased risk of fractures; hence patients at risk of osteoporosis should consult their physician. This drug interacts with many other medications, so it is essential to inform the doctor or pharmacist about any other medications being taken. Caution is needed when used with anticoagulants, anticonvulsants, certain antibiotics, and antiviral agents. The safety of this medication during pregnancy has not been sufficiently established, so pregnant women should use it cautiously according to a doctor's guidance, and it is recommended that nursing mothers do not take this medication. In case of overdose, since there is no specific antidote, it is important to receive appropriate treatment based on symptoms. Lastly, this medication should be kept out of reach of children, and it is best not to transfer it into other containers.

Serious side effects

Urticaria, angioedema, anaphylaxis, shock, severe allergic reactions, severe rash with fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, severe skin reaction, difficulty breathing or shortness of breath, asthma attack, respiratory issues accompanied by coughing and fever, yellowing of skin or eyes (jaundice), overall lethargy, liver dysfunction (jaundice), sudden and severe headache, thunderclap headache, seizures, confusion.

Mild side effects

Itching, rash, insomnia, anxiety, mental confusion, depression, aggression, hallucinations, dizziness, perceptual abnormalities, drowsiness, taste disturbances, blurred vision, bronchospasm, abdominal pain, constipation, diarrhea, abdominal bloating, nausea, vomiting, dry mouth, stomatitis, gastrointestinal candidiasis, elevated liver enzymes, hepatitis, fractures, joint pain, muscle pain, weakness, hyperhidrosis, blood abnormalities (leukopenia, thrombocytopenia, etc.), fever, angioedema, peripheral edema.

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. The recommended storage temperature is room temperature between 1°C and 30°C. This helps to maintain the drug's effectiveness and safety for a long time.

Appearance

Pink round film-coated tablets

Package unit

28 Tablets/Box[(7 Tablets/PTP x 4)]