Donepezil 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. After administering 5 mg for 4 to 6 weeks, clinical response should be evaluated for a possible increase to 10 mg. For dosage increase to 10 mg per day, caution is required regarding gastrointestinal adverse reactions. Underweight women over 85 years should not exceed 5 mg per day, and careful monitoring for adverse reactions is required.

Child dose

There is no experience with the use in children.

This medication contains Donepezil Hydrochloride Hydrate as its active ingredient and is used for the treatment of symptoms of Alzheimer's type dementia. This medication should not be used in certain patients. For instance, individuals who are allergic to this medication or its components, pregnant women or those who may become pregnant, breastfeeding women, and patients with lactose intolerance or specific genetic lactose metabolism disorders should not take this medication. Patients with heart disease or heart conduction disorders need to take caution when using this medication, as it may slow down the heart rate or cause arrhythmias. Patients taking nonsteroidal anti-inflammatory drugs or with a history of peptic ulcer disease should also be careful when using this medication, as there is a possibility of gastrointestinal bleeding or exacerbation of ulcers. Patients with asthma or obstructive lung disease should use cautiously, as bronchoconstriction or increased mucus secretion may worsen symptoms. Patients with extrapyramidal disorders such as Parkinson’s disease may experience worsening symptoms, and caution is required. This medication contains Yellow No. 5 dye, which may cause allergic reactions in some individuals. When taking this medication, various adverse reactions may occur. Cardiac issues such as fainting, bradycardia, and heart block may happen, and gastrointestinal bleeding or ulcers, liver dysfunction, cerebral hemorrhage, seizures, muscular abnormalities, respiratory distress, pancreatitis, and renal failure have been reported. Additionally, side effects such as hallucinations, anxiety, insomnia, dizziness, diarrhea, nausea, vomiting, loss of appetite, headache, fatigue, skin rashes may occur. If there is no treatment effect for dementia, it is recommended to discontinue use, and treatment should occur under the supervision of an experienced physician. This medication can affect heart rhythm, so patients with heart diseases or a history of prolonged QT interval should be particularly cautious, and an electrocardiogram may be necessary in some cases. Caution is advised when driving or operating machinery, especially during the initial dose or dosage increase. Pregnant or breastfeeding women are advised against using this medication and should consult specialists if necessary. This medication can interact with various drugs, so it is essential to inform the physician or pharmacist of any other medications being taken. In case of overdose, symptoms such as nausea, vomiting, bradycardia, hypotension, respiratory depression, and convulsions may occur, and immediate medical attention is necessary. This medication should be kept out of the reach of children, and transferring it to other containers should be avoided.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, peeling skin, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory issues accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme body weakness, sudden and severe headache, lightning headache, seizures, altered consciousness, visual disturbances, paralysis, urination

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• drowsiness
• dizziness
• insomnia
• anxiety

This medication should be stored in a tightly closed container to prevent air or moisture from entering. It is recommended to store it at room temperature, between 1 to 30 degrees Celsius, to maintain its effectiveness over time.

Appearance

Yellow circular film-coated tablet

Package unit

30 tablets/bottle