Medication info

Clopirel Duo Capsule

Prescription medicationHard capsuleApproval withdrawn
Ingredient · strength
Clopidogrel Bisulfate›97.875mg / 1 capsuleAspirin Enteric Pellets›122mg / 1 capsule
Manufacturer / importer
(주)셀트리온제약
Appearance
An orange hard capsule containing white or pale yellow granules and enteric-coated pellets
Packaging
30 capsules/bottle, 300 capsules/bottle
Approval status
Approval withdrawn

MFDS item code 201508428 · Approved 2015.12.24 · Insurance code 693902000

This product's status changed to Approval withdrawn on 2025.08.28. It may no longer be sold, so consult a doctor or pharmacist before taking it.

Summary

Main use
Improvement of atherosclerotic symptoms and reduction of thromboembolism risk in acute coronary syndrome (cardiovascular anomalies) and atrial fibrillation (stroke, etc.)
Who uses it
Adults
Adult dosage
1 capsule once daily.

Ingredients

Manufacturer
(주)셀트리온제약

Efficacy & effects

Improvement of atherosclerotic symptoms and reduction of thromboembolism risk in acute coronary syndrome (cardiovascular anomalies) and atrial fibrillation (stroke, etc.)

  • Acute coronary syndrome
  • unstable angina
  • non-ST elevation myocardial infarction
  • atherosclerotic symptoms
  • cardiovascular anomalies
  • myocardial infarction
  • stroke
  • refractory ischemia
  • vascular risk factors
  • bleeding risks
  • atrial fibrillation
  • atherothrombosis
View approved original text

This drug is used in patients with acute coronary syndrome, such as those with unstable angina or non-ST elevation myocardial infarction. It also improves atherosclerotic symptoms such as death due to cardiovascular anomalies, myocardial infarction, stroke, or refractory ischemia in patients who have received drug therapy or coronary intervention (PCI), and coronary artery bypass grafting (CABG). Additionally, it is used to reduce the risks of stroke and thromboembolism in atrial fibrillation patients who possess one or more vascular risk factors and in whom vitamin K antagonists are inappropriate and bleeding risks are low. In summary, this drug is used for thrombus prevention and improvement of cardiovascular complications in specific cardiovascular disease patients.

Dosage and Administration

Adult dosage

1 capsule once daily.

Precautions

This medication prevents blood from clotting and the formation of thrombosis. Taking this medication may prolong the time it takes for bleeding to stop, so if bleeding is severe or lasts a long time, you should immediately inform your doctor. You must inform your healthcare provider that you are taking this medication before undergoing surgery or dental treatment, or before starting any new medication. If you genetically metabolize the active ingredient of this medication poorly, the effectiveness of the medication may decrease, leading to more frequent cardiovascular problems, so caution is required. Taking certain medications in combination may increase the risk of bleeding, so do not use other drugs without consulting your physician. Those who drink alcohol heavily every day should consult a professional as there is a risk of gastrointestinal bleeding when taking this medication. This medication should not be taken by individuals who are allergic to it or have specific bleeding disorders, severe liver dysfunction, renal impairment, or cardiac dysfunction. Women in late pregnancy or breastfeeding should also not take this medication. Patients with a history of gastrointestinal bleeding or those with a tendency to bleed, as well as those with blood disorders, must exercise caution when taking this medication as the risk of bleeding is high. Patients scheduled for surgery should discontinue this medication 5-7 days before surgery and resume it only after hemostasis. The risk of bleeding is increased when this medication is used concurrently with other antiplatelet agents or anticoagulants, so concurrent use is not recommended. During the course of taking this medication, it is crucial to monitor for gastrointestinal symptoms or bleeding symptoms, and if any abnormal signs appear, consult your healthcare provider immediately. This medication is not recommended for children or adolescents under 18 years old, as safety and efficacy in this population have not been established. It does not affect the ability to drive or operate machinery, but caution is needed due to the risk of bleeding. In the case of overdose, bleeding may become severe, and since there is no specific antidote, platelet transfusions may be required in case of bleeding. This medication should be stored at room temperature away from children and protected from air and moisture.

Side effects and when to seek care immediately

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, mucosal pain in the mouth/eyes, shortness of breath or difficulty breathing, asthma attack, cough+fever accompanied respiratory abnormalities, skin or eye jaundice, profound lethargy, sudden and very severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urination

Mild side effects

  • Headache
  • dizziness
  • abdominal pain
  • dyspepsia
  • diarrhea
  • nausea
  • fatigue
  • rash
  • pruritus
  • insomnia
Show 29 more
  • depression
  • myalgia
  • arthralgia
  • low back pain
  • bloody stools
  • epistaxis
  • anemia
  • cough
  • rhinitis
  • thrombocytopenia
  • hematuria
  • hemoptysis
  • dry eyes
  • visual disturbances
  • urinary disorders
  • hypoglycemia
  • elevated liver enzymes
  • weight gain
  • weight loss
  • flushing
  • syncope
  • palpitations
  • anxiety
  • urticaria
  • contact dermatitis
  • impaired platelet function
  • tinnitus
  • voice disorder
  • exercise

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is important to maintain the storage temperature between 1 degree and 30 degrees Celsius.

Appearance and packaging

Appearance

An orange hard capsule containing white or pale yellow granules and enteric-coated pellets

Package unit

30 capsules/bottle, 300 capsules/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.