Acibav Tablet (Acyclovir)

Adult administration

1. Treatment of herpes simplex virus infections - Administer 200 mg five times a day at 4-hour intervals for 5 days. - In cases of severe primary infection, treatment may be extended. - For patients with severe immune deficiency or gastrointestinal absorption disorders, increase to 400 mg at a time or consider intravenous administration. 2. Prevention of herpes simplex infections in patients with normal immune function - Administer 200 mg four times a day at approximately 6-hour intervals.

Child administration

1. Treatment of herpes simplex infections and prevention of herpes simplex infections in immunocompromised patients - Ages 2 and older: same as adults - Under 2 years: administer 1/2 of the adult dose - There is currently no definitive data on the prevention of herpes simplex virus infections in patients with normal immune function.

This medication should not be used in patients who have had an allergic reaction to this drug or its components, including valacyclovir. Caution should be exercised when used in patients with impaired renal function, as neurological side effects may occur; similarly, it should be administered carefully in patients with reduced liver function due to the risk of further deterioration. Use with caution in children, infants, and the elderly. Particularly for the elderly, renal function is often diminished, which may lead to increased drug concentration, necessitating adjustment of dosage and administration intervals. During treatment with this medication, severe allergic reactions such as anaphylactic shock may rarely occur; if symptoms such as difficulty breathing, hypotension, or chest tightness develop, discontinue use immediately and notify medical personnel. Photosensitive reactions or hypersensitivity reactions such as skin rash, fever, blisters, and urticaria may occur; if such symptoms arise, discontinue administration and seek appropriate treatment. Skin-related adverse effects can include hair loss, severe skin reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis, which are rarely seen. Neurological side effects include altered consciousness, confusion, hallucinations, seizures, drowsiness, tremors, anxiety, and insomnia, and may occur more frequently in the elderly or patients with reduced renal function. Renal complications may manifest as renal failure, hematuria, or proteinuria, necessitating regular monitoring of renal status. Hematologic and lymphatic system abnormalities may result in leukopenia, anemia, bleeding, and purpura; any unusual symptoms should prompt immediate consultation with medical personnel. Liver dysfunction, hepatitis, and symptoms of jaundice may develop, so regular liver function tests are recommended. Gastrointestinal side effects may include gastritis, nausea, vomiting, diarrhea, and abdominal pain; if symptoms are severe, discontinue use of the medication. This medication is used to treat herpes zoster, chickenpox, and herpes simplex, with particularly effective administration within 3-5 days of symptom onset. Sufficient hydration is necessary during treatment, and particularly during high-dose administration to prevent dehydration and minimize the risk of renal toxicity. Caution is needed when driving or operating machinery due to possible side effects such as altered consciousness or drowsiness. This drug may interact with other medications; consult with medical personnel if taken in conjunction with probenecid, cimetidine, theophylline, or mycophenolate mofetil. Women who are pregnant or may become pregnant should only use this medication if the benefits outweigh the risks of teratogenic effects, and breastfeeding should be discontinued as the drug can be passed into breast milk. In case of overdose, neurological symptoms and renal failure may occur; immediate medical attention is required, and blood dialysis may be necessary if needed.

Serious side effects

• Urticaria
• severe swelling
• hypotension
• difficulty breathing
• chest tightness
• shock
• anaphylactic shock
• anaphylaxis-like reaction
• toxic epidermal necrolysis
• Stevens-Johnson syndrome

Mild side effects

• Photosensitivity reactions
• fixed drug eruptions
• rashes
• fever
• blisters
• hair loss
• erythema multiforme
• altered consciousness
• disorientation
• attention deficit

This medication should be stored according to different methods for domestic and export formulations. The domestic formulation should be kept in a sealed container to prevent air exposure, stored in a dry place below 25 degrees Celsius. The export formulation should also be stored in a sealed container, at a temperature between 1 and 30 degrees Celsius.

Appearance

For domestic use: light blue round tablets; for export: pale blue round tablets.

Package unit

30 tablets/bottle, 100 tablets/bottle