Sitagliptin 50 mg Tablets (Sitagliptin Phosphate)

Adult dose

This medication is administered once daily at a dosage of 100 mg, with a maximum daily dose of 100 mg. It can be taken regardless of meals. In patients with kidney impairment, dosage adjustments according to kidney function are necessary. - For mild and moderate renal impairment (eGFR ≥ 45 and < 60), dosage adjustments are not necessary. - For moderate renal impairment (eGFR ≥ 30 and < 45), the dosage is 1

This medication may rarely cause serious allergic reactions. Possible reactions include severe skin rashes or swelling and shortness of breath; if these symptoms occur, use should be stopped immediately and advice sought from a doctor. Additionally, this medication can cause pancreatitis, an inflammation of the pancreas. Symptoms of pancreatitis include abdominal pain, vomiting, and nausea; if these symptoms occur, medication should be stopped immediately and medical attention sought. It should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and is also contraindicated in patients with a known allergy to this medication or its components. Patients with impaired kidney function may not adequately excrete the medication from the body, requiring dosage adjustments or careful use, as regular kidney function tests are recommended. Adverse effects reported from clinical trials and post-marketing surveillance include upper respiratory infections, headaches, nasopharyngitis, diarrhea, and particularly, there may be an increased risk of hypoglycemia when used with insulin or sulfonylureas, necessitating careful blood sugar monitoring. Furthermore, if during the use of this medication there is severe joint pain, muscle pain, skin blisters, or rashes, it is critical to inform a doctor and potentially discontinue use. The safety of this medication has not been established in pregnant or breastfeeding women; therefore, it is recommended to avoid use in those situations. In cases of overdose, gastrointestinal decontamination should be conducted, and monitoring of cardiovascular status, such as ECG, should occur; some medication may be removed via hemodialysis if necessary. Lastly, this medication can increase the risk of hypoglycemia when used in combination with other hypoglycemic agents, making it important to consult with a doctor or pharmacist about interactions with other medications being taken.

Serious side effects

Urticaria, severe swelling (angioedema), anaphylaxis, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, oral/ocular mucosal pain, Stevens-Johnson syndrome, acute pancreatitis, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice of the skin or eyes, extreme malaise, liver abnormalities, sudden and severe headaches, etc.

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• constipation
• vomiting
• headache
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in a tightly sealed container to prevent air exposure, ideally at a temperature between 1°C to 30°C. Proper storage will help maintain its effectiveness.

Appearance

Light beige, round, biconvex film-coated tablet

Package unit

28 tablets (14 tablets/PTP × 2)