Hydone 5 mg Tablet (Donepezil Hydrochloride Monohydrate)

Adult dose

As Donepezil Hydrochloride, administer 5 mg once daily before bedtime. Administer 5 mg for 4-6 weeks, after which dosage may be increased to 10 mg based on clinical response evaluation. Caution should be taken for gastrointestinal adverse reactions when increasing to 10 mg per day. Underweight females aged 85 years or older should not exceed 5 mg per day and require careful monitoring.

Child dose

There is no experience in using it in pediatric patients.

This medication contains Donepezil Hydrochloride Monohydrate as the active ingredient and is used for the treatment of Alzheimer's disease. First, this medication should not be administered to certain patients. For instance, it should not be used in individuals who are allergic to this medication or its components, pregnant women or those who may become pregnant, nursing mothers, and patients with genetic lactose intolerance. Moreover, patients with heart disease or heart conduction disorders, those with a history of peptic ulcer or taking non-steroidal anti-inflammatory drugs, those with a history of asthma or obstructive lung disease, as well as patients with extrapyramidal disorders such as Parkinson's disease should use this medication with caution. This medication can slow the heart rate or cause arrhythmias, lead to gastrointestinal bleeding or worsening of symptoms, and may exacerbate asthma symptoms. Various adverse reactions may occur during the administration of this medication. Common symptoms include nausea, vomiting, diarrhea, dizziness, insomnia, headache, and fatigue, while rare but serious reactions can include severe heart problems, liver dysfunction, cerebrovascular disorders, and muscle abnormalities, necessitating immediate consultation with a physician if severe symptoms arise. This medication should only be used in patients with Alzheimer's disease and is not approved for other types of dementia or cognitive decline. Treatment should be conducted under the supervision of an experienced physician, with regular evaluations of the patient's condition to discontinue treatment if no effect is observed. Caution is needed as it may affect the cardiovascular system, especially in individuals with heart disease or ECG abnormalities, where ECG monitoring may be required. Additionally, caution should be exercised as this medication may impair driving or operating machinery, particularly during the initial dosing or dose escalation, where dizziness or muscle cramps may occur. It is advisable for pregnant or nursing women to avoid using this medication, and it is essential to consult a specialist if necessary. Safety in children has not been established, and therefore it should not be used in pediatric patients. This medication may affect liver and kidney function; thus, regular clinical examinations to monitor status are important. In the event of an overdose, severe symptoms such as severe nausea, vomiting, bradycardia, respiratory depression may occur, requiring immediate emergency treatment, where atropine can be used as an antidote. Finally, this medication may interact with other drugs; thus, caution is necessary, especially when used in conjunction with cardiac medications, antidepressants, antibiotics, and anticholinergic medications, and consultation with a physician or pharmacist is imperative.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with fever, blisters, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities with coughing and fever, yellowing of the skin or eyes (jaundice), profound lethargy, sudden and severe headaches, lightning-like headaches, seizures, confusion of consciousness, visual disturbances, paralysis, urinary abnormalities.

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headache
• fatigue
• insomnia
• dizziness
• tremors
• muscle pain

This medication should be stored in a sealed container to prevent air exposure, ideally at room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the medication's efficacy for a longer period.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle