Anaprazole 20 mg Tablets (Esomeprazole Magnesium Trihydrate)

Adult dosage

This medication should be swallowed with liquids like water and should not be chewed or crushed. 1) Gastroesophageal reflux disease (GERD) - For the treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks. If esophagitis is not resolved or symptoms continue, take for an additional 4 weeks. - Long-term maintenance therapy for preventing recurrence in patients with esophagitis: 20 mg once daily. - For the symptom treatment of gastroesophageal reflux disease without esophagitis: · 20 mg once daily. If symptoms are not controlled after 4 weeks, further medical attention is needed. · Once symptoms alleviate, subsequent symptoms should be controlled with 20 mg once daily. · In adults, it is possible to take 20 mg once daily as needed. Patients at high risk for gastric ulcers and duodenal ulcers due to non-steroidal anti-inflammatory drug use are not recommended to take it as needed for continuous symptom control. 2) Combination therapy with antibiotics for the eradication of Helicobacter Pylori: 20 mg of this medication with 1 g of amoxicillin and 500 mg of clarithromycin, administered twice daily for 7 days. 3) Short-term therapy for treating upper gastrointestinal symptoms (pain, discomfort, burning) related to the use of non-steroidal anti-inflammatory drugs (non-selective and selective COX-2): 20 mg once daily. If symptoms are not controlled after 4 weeks, further medical consultation is needed. Clinical trials beyond 4 weeks have not been conducted. 4) For patients requiring continuous non-steroidal anti-inflammatory drug use - Treatment of gastric ulcers related to non-steroidal anti-inflammatory drugs: 20 mg once daily. The treatment duration is 4 to 8 weeks. - Prevention of gastric and duodenal ulcers related to non-steroidal anti-inflammatory drugs: 20 mg once daily. 5) Treatment of Zollinger-Ellison syndrome The recommended initial dose is 40 mg twice daily. Subsequent doses should be adjusted based on the individual patient's needs, and treatment should continue as long as clinical symptoms are present. According to clinical data, the majority of patients can be managed on doses of 80 to 160 mg daily. Doses exceeding 80 mg should be divided into two daily doses. 6) Maintenance therapy after intravenous induction of prevention for rebleeding due to gastric or duodenal ulcers 40 mg once daily for 4 weeks after intravenous induction for the prevention of rebleeding due to gastric or duodenal ulcers. 2. Adolescents aged 12 and older 1) Gastroesophageal reflux disease (GERD) - For the treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks. If esophagitis is not resolved or symptoms persist, an additional 4 weeks of use is required.

Children's dosage

Adolescents aged 12 and older: - For the treatment of erosive reflux esophagitis: 40 mg once daily for 4 weeks. If esophagitis is not resolved or symptoms persist, an additional 4 weeks of use is required.

This medication should not be used in individuals with allergies or a history of hypersensitivity to certain ingredients or benzimidazole derivatives. Patients taking some antibiotics or antivirals used in the eradication of Helicobacter pylori should also avoid this medication, as well as those with a history of myocardial infarction or those who are breastfeeding. This medication contains a dye called Yellow No. 5, so people with allergy reactions to this ingredient should use it with caution. Rarely, the use of this medication may result in various side effects such as blood abnormalities, allergic reactions, electrolyte imbalances, neurological symptoms, gastrointestinal disturbances, liver dysfunction, skin rashes, and more. If any symptoms arise, immediate consultation with a physician is required. Long-term use of this medication may lead to electrolyte imbalances such as hypomagnesemia, necessitating regular testing. Moreover, since this medication suppresses gastric acid secretion, there is a slightly increased risk of bacterial infections in the gastrointestinal tract, so if abnormal symptoms such as diarrhea persist, the healthcare provider should be informed. Patients at risk of osteoporosis or fractures should be cautious, as the long-term use of this medication may increase the risk of fractures. This medication can interact with various drugs, so if other medications are being taken, individuals must inform their healthcare provider, particularly when used alongside anticoagulants, antibiotics, antivirals, and anticonvulsants. Women who are pregnant or breastfeeding must consult with a physician before using this medication, and it is safest for breastfeeding mothers not to use this medication. In the case of overdose, there is no specific antidote available, so appropriate treatment should be provided according to symptoms, and it should be kept out of reach of children.

Serious side effects

Urticaria, angioedema, anaphylaxis reaction/shock, severe allergic reactions, severe edema, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, eosinophilia with systemic symptoms drug reaction (DRESS syndrome), jaundice, liver failure, liver abnormalities, sudden and severe headache, seizures, altered consciousness, vision changes, paralysis, breathing problems, bronchospasm.

Mild side effects

• Leukopenia
• thrombocytopenia
• agranulocytosis
• pancytopenia
• fever
• peripheral edema
• hyponatremia
• hypomagnesemia
• insomnia
• anxiety

This medication can be sensitive to air or moisture, so it should be stored in a tightly closed container. Additionally, it is important to store it at room temperature between 1°C and 30°C to maintain its effectiveness.

Appearance

Pale pink round film-coated tablet

Package unit

Box - 28 tablets/box [14 tablets/PTP x 2]