Wibisd Tablets

Adult dose

For adults, typically taken orally as 1 tablet twice daily, before breakfast and at bedtime, regardless of meals. 1) Gastric and duodenal ulcers: Administer 1 tablet twice daily or 2 tablets once daily at bedtime. For duodenal ulcer patients, taking 2 tablets twice daily before breakfast and bedtime can achieve a higher treatment rate. The dosage is the same for combination therapy with medications due to NSAID use or for preventing gastric and duodenal ulcer occurrence due to long-term NSAID use. Typically, diseases due to NSAID use heal within 8 weeks, although sometimes healing may take longer depending on the patient. For recurrent ulcer patients who have had excellent results with short-term therapy, maintain therapy with 1 tablet once daily at bedtime. 2) Gastroesophageal reflux disease: Administer 1 tablet twice daily for 8 weeks or 2 tablets once daily at bedtime. For severe gastroesophageal reflux disease patients, the dosage can be increased to 2 tablets four times daily. 3) Zollinger-Ellison syndrome: Start treatment with an initial dose of 1 tablet three times daily, and increase as necessary. For severe cases, under doctor's guidance, a daily dosage of up to 6 grams of ranitidine can be provided. 4) Peptic ulcers, acute stress ulcers, and upper gastrointestinal bleeding due to acute gastric mucosal lesions: Once oral administration is possible, switch from injection to oral administration, taking 1 tablet twice daily. 5) Preoperative medication (prevention of Mendelson's syndrome): Administer 1 tablet 2 hours before induction of anesthesia. It is even better to administer 1 tablet the night before surgery.

This drug should not be used in patients with severely impaired kidney function or those on dialysis. Additionally, it is safe not to administer this drug to patients who have had allergic reactions to it or its ingredients. This drug is also not recommended for patients with a history of acute porphyria, which is a rare condition. It is advised not to administer to women who are pregnant or may become pregnant, as well as to premature or newborn infants. Patients on diets that restrict potassium intake should also avoid this drug. Patients with compromised liver function, those with a history of drug allergic reactions, elderly patients, and patients with kidney issues should exercise caution when using this medication. When taken alongside non-steroidal anti-inflammatory drugs, especially elderly patients or those with a history of peptic ulcers need regular monitoring. This drug can mask symptoms of stomach cancer, so patients with gastric ulcers or those over middle age who have newly developed or changed dyspeptic symptoms should confirm whether malignancy is present before treatment. For patients with gastric or duodenal ulcers who test positive for Helicobacter pylori, eradication treatment is necessary. Patients in intensive care units may develop gastric stones, hence caution is necessary. Patients with hypophosphatemia should be cautious as the aluminum component in this drug can interfere with phosphate absorption. Patients with swallowing difficulties may experience respiratory complications after taking this drug, thus should be careful. Symptoms such as shock, skin rash, hives, or difficulty breathing due to allergic reactions may occur, so if any unusual symptoms arise, discontinue use immediately and consult a healthcare professional. Blood tests may show decreased white blood cell or platelet counts, and liver function test results can temporarily increase. Cardiovascular side effects such as arrhythmias or vasculitis have also been reported rarely. Gastrointestinal symptoms may include nausea, vomiting, constipation, diarrhea, and abdominal pain, and the color of the stool may change; however, this does not require special treatment. Severe dizziness, drowsiness, confusion, and seizures may occur as rare neurological symptoms, so inform a healthcare professional immediately if these symptoms appear. Muscle pain or joint pain can occur, and in severe cases, rhabdomyolysis can cause muscle tissue damage, requiring caution. Skin-related side effects such as rashes or hair loss may also occur rarely. It is advisable not to use this drug for an extended period, and if no therapeutic effect is observed, switching to another medication is preferable. Elderly patients or those with chronic pulmonary disease, diabetes, and reduced immunity may have an increased risk of pneumonia while taking this medication, so caution is warranted. If dizziness or drowsiness occurs after administration, it is safer to avoid driving or operating dangerous machinery. This drug may interact with other medications, so if taking anticoagulants or certain antibiotics or anticonvulsants, inform healthcare providers and manage carefully. It is safest not to use this drug in pregnant or nursing women. Safety in children has not been sufficiently confirmed, so administration should be avoided if possible. In cases of overdose, emergency measures such as vomiting or gastric lavage may be necessary, and blood dialysis may be beneficial in some cases. This drug suppresses gastric acid secretion, which can promote bacterial growth in the stomach; therefore, regular monitoring, including eye exams, is necessary for long-term use.

Serious side effects

Hives, angioedema, bronchospasm, shock (anaphylactic shock), severe swelling (edema), tightness in the chest, difficulty breathing, chest pain, blood system abnormalities (granulocytopenia, leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, aplastic anemia, acquired immune hemolytic anemia), liver abnormalities (jaundice, hepatitis, impaired liver function), arrhythmias (tachycardia, bradycardia, AV block, premature ventricular contractions), vasculitis, severe skin reactions

Mild side effects

• Skin rash
• angioedema
• fever
• low blood pressure
• chest pain
• nausea
• vomiting
• constipation
• diarrhea
• abdominal distension

This medication must be stored in a tightly sealed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 to 30 degrees Celsius. This way, the medication's effectiveness can be preserved for a longer time.

Appearance

Greenish rectangular film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle