Rosuvastatin Calcium/Ezetimibe 10/10 mg

Adult dose

This medication should be administered once daily, irrespective of meals. For primary hypercholesterolemia, an initial dose of 10/5 mg daily is recommended, with a dosage range of 10/5 mg to 10/20 mg per day. Patients requiring more reduction in LDL cholesterol may have their dosage adjusted, with lipid levels being monitored at intervals of more than four weeks to adjust the dosage accordingly. The maximum daily dosage can be increased up to 10/20 mg.

This medication may cause muscle problems, and if severe muscle pain or weakness occurs, the physician should be notified immediately. There is a risk of impaired kidney function due to muscle damage; therefore, it may be necessary to temporarily discontinue this medication in cases of serious infections, surgeries, or trauma. Patients with allergies to any of this medication's components, severe liver or kidney dysfunction, muscle diseases, or those who are pregnant or breastfeeding should not take this medication. Patients with severe kidney dysfunction or abnormal liver function should use this medication with caution and undergo regular liver function tests and muscle-related examinations. This medication may elevate liver enzyme levels, so patients with a history of liver disease or those who consume alcohol heavily should exercise caution. Blood glucose levels may increase; therefore, diabetic patients should manage their blood glucose levels diligently. This medication may interact with other drugs, so individuals taking other medications should inform their physician or pharmacist, especially when co-administered with anticoagulants, fibrates, certain antibiotics, or antifungal agents. The safety of this medication has not been thoroughly established for children and adolescents; thus, it is not recommended for pediatric patients. Elderly patients face a higher risk of muscle issues and should use this medication with extra caution. Women who are pregnant or may become pregnant should consult a healthcare provider before starting this medication and should use appropriate birth control methods. If severe skin rashes, fever, or swelling occur while taking this medication, it should be discontinued immediately, and medical advice should be sought. There is no specific antidote for overdose, so treatment should be symptomatic, and liver function and muscle enzyme levels should be monitored. This medication should be stored out of reach of children, and transferring to other containers should be avoided.

Serious side effects

Urticaria, edema, chest tightness, cold sweat, severe allergic reaction, severe skin adverse reaction, difficulty breathing, dyspnea, jaundice, liver abnormalities, sudden and severe headache, confusion, paralysis, severe neurological symptoms, significant decrease in urine output, increased blood pressure, severe edema or urination abnormalities, rhabdomyolysis, acute renal failure, immune-mediated necrotizing myopathy, Stevens-Johnson syndrome, systemic symptoms accompanying medication

Mild side effects

• Pharyngitis
• dyspepsia
• headache
• dizziness
• constipation
• nausea
• abdominal pain
• dry mouth
• pruritus
• itching

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is also safest to store it at room temperature, between 1 to 30 degrees Celsius, without extreme heat or cold.

Appearance

Yellow, rectangular film-coated tablet

Package unit

30 tablets/PTP [10 tablets/PTP x 3], 30 tablets/bottle, 100 tablets/bottle