Urigat Tablet 80mg (Febuxostat)

Adult dosage

1. Adults This medicine is administered at a dose of 40 mg or 80 mg once daily, regardless of meals. Because this medicine acts very rapidly, serum uric acid levels should be rechecked after 2 weeks. The treatment goal is to lower and maintain serum uric acid levels below 6 mg/dL(357 μmol/L). 2. Patients with renal impairment No dose adjustment is necessary in patients with mild or moderate renal impairment. The safety and efficacy of this medicine have not been adequately evaluated in patients with severe renal impairment (creatinine clearance less than 30mL/min). 3. Patients with hepatic impairment No special dose adjustment is necessary in patients with mild or moderate hepatic impairment. Only limited information is available for patients with moderate hepatic impairment, and the efficacy and safety of this medicine have not been studied in patients with severe hepatic impairment (Child Pugh class C).

This medication may increase the risk of cardiovascular death when used in patients with cardiovascular disease, so caution is advised if there is a history of cardiovascular disease. Patients who are allergic to the main ingredient of this medication or its excipients, those taking specific drugs (Mercaptopurine, Azathioprine), and those with genetic issues such as lactose intolerance should not take this medication. Patients with a history of liver disease should undergo regular liver function tests during treatment with this medication, and caution is also required for patients with thyroid dysfunction. Patients with heart disease or heart failure, as well as those taking specific medications (Theophylline), should be careful when using this medication. Do not start taking this medication during an acute gout attack, and initial treatment may temporarily worsen gout attacks, so it should be used with appropriate management. This medication can cause various side effects such as liver dysfunction, diarrhea, headaches, rashes, dizziness, etc., so if any abnormal symptoms occur, consult a healthcare professional immediately. If symptoms of liver dysfunction appear, discontinue use immediately and seek testing; if liver enzyme levels significantly rise, re-administration should be avoided. This medication may cause drowsiness and dizziness, so caution should be exercised when driving or operating dangerous machinery. Pregnant or breastfeeding women are advised to avoid taking this medication, and there is no experience in administration for children under 18 years old, so it should not be administered to them. In case of overdose, there is no specific antidote, so symptomatic treatment should be received, and it should be stored out of reach of children. There may be interactions with other drugs, so especially patients taking Mercaptopurine, Azathioprine, Theophylline should inform their healthcare provider and use caution when combining medications.

Liver dysfunction, dizziness, diarrhea, headache, rash, nausea, fatigue, joint pain, limb pain, gout, myalgia, pruritus, shortness of breath, anemia, idiopathic thrombocytopenic purpura, leukocytosis, leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia, angina, atrial fibrillation, atrial flutter, heart murmur, abnormal electrocardiogram, palpitations, bradycardia, tachycardia, hearing loss, tinnitus, vertigo, blurred vision, abdominal distension, abdominal pain, constipation, dry mouth, dyspepsia, flatulence, increased bowel frequency, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gum pain, hematemesis, excessive gastric acid, passage of blood in stool, oral ulcers, pancreatitis, gastric ulcer, vomiting, weakness, chest pain, chest discomfort, edema, emotional disturbances, walking difficulties, influenza-like symptoms, mass, pain, thirst, cholelithiasis, diabetes insipidus, fatty liver, hepatitis, hepatomegaly, hypersensitivity, herpes zoster, loss of appetite, decreased appetite, increased appetite, dehydration, diabetes mellitus, hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, hypokalemia, weight loss, weight gain, arthritis, joint stiffness, joint swelling, muscle cramps, muscle fasciculation, muscle contraction, muscle weakness, musculoskeletal pain, muscle rigidity, altered taste, balance disturbances, cerebrovascular accident, Guillain-Barré syndrome, headache, partial paralysis, sensory loss, hyposmia, heat stroke, drowsiness, mental disorder, migraine, sensory disturbances, drowsiness, transient ischemic attack, tremor, agitation, anxiety, depression, insomnia, excitability, decreased libido, neuroticism, panic attacks, personality changes, hematuria, nephrolithiasis, increased urination, proteinuria, renal failure, renal insufficiency, urgency, incontinence, breast pain, erectile dysfunction, gynecomastia, bronchitis, cough, shortness of breath, epistaxis, nasal dryness, excessive sinus secretion, pharyngeal edema, airway congestion, sneezing, throat irritation, upper respiratory infection, alopecia, angioedema, dermatitis, skin urticaria, petechial hemorrhage, eczema, hair discoloration, abnormal hair growth, hyperhidrosis, skin exfoliation, petechiae, photosensitivity, pruritus, purpura, skin discoloration, changes in skin pigmentation, skin lesions, axillary hyperhidrosis, urticaria, flushing, facial flushing, hypertension, hypotension, prolongation of activated partial thromboplastin time, increased creatinine, decreased bicarbonate, increased sodium, abnormal EEG, increased glucose, increased cholesterol, increased triglycerides, increased amylase, increased potassium, increased thyroid-stimulating hormone, decreased platelets, decreased hematocrit, decreased hemoglobin, increased mean corpuscular volume, decreased red blood cells, increased creatinine, increased blood urea nitrogen, increased blood urea to creatinine ratio, increased CPK, increased ALP, increased LDH, increased PSA, decreased urine output, decreased lymphocyte count, decreased neutrophil count, fluctuating white blood cell count, abnormal coagulation tests, increased low-density lipoprotein, prolonged prothrombin time, urinary casts, positive urine leukocytes and protein, contusion, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute anaphylactic reaction, shock, severe allergic reactions, hypersensitivity, liver failure, jaundice, liver dysfunction, agranulocytosis, rhabdomyolysis

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is important to maintain a storage temperature between 1 to 30 degrees Celsius (33.8 to 86 degrees Fahrenheit).

Appearance

Light yellow to yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle