Atorren Tablets 20 mg (Atorvastatin Calcium Trihydrate)

Adult dosage

The recommended initial dose for hyperlipidemia is 10 mg of atorvastatin once daily, or if greater LDL cholesterol reduction is required, start at 20 mg or 40 mg once daily. This medication is administered in a dosage range of 10 to 80 mg once daily. The initial and maintenance doses should be individualized based on the treatment goal and patient response, and lipid levels should be analyzed within 2 to 4 weeks after initiation and/or dose adjustment to adjust the dosage accordingly. The treatment aim is to lower LDL cholesterol levels; therefore, LDL cholesterol levels should be used for both the start of treatment and evaluation of treatment response. If LDL cholesterol levels cannot be used, total cholesterol levels should be used to monitor treatment response. For patients with homozygous familial hypercholesterolemia, the dosing regimen is 10 to 80 mg once daily, used either in conjunction with other lipid-lowering treatments (e.g., LDL apheresis) or when such treatments are not possible. In pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17), the recommended initial dose is 10 mg once daily, and the recommended maximum dose is 20 mg once daily (there is no clinical data for doses higher than 20 mg in this age group). The dosage should be adjusted appropriately based on the recommended therapeutic target for each individual patient. Dosage adjustments should be made with an interval of 4 weeks or more. ○ Patients with renal impairment: Renal disease does not affect atorvastatin plasma concentration or LDL cholesterol-lowering effect; therefore, dose adjustment is unnecessary. ○ Elderly patients: Efficacy and safety in patients over 70 years old are similar to that of average adult patients.

Children's dosage

The recommended initial dose for pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17) is 10 mg once daily, with a maximum dose of 20 mg once daily. Dosage adjustments should be made with an interval of 4 weeks or more.

This medication may pose a risk of muscle problems; if symptoms like muscle pain or weakness occur, discontinue use immediately and consult a physician. This medication should not be used by patients with certain diseases, such as those with liver or muscle disorders, pregnant women or those who may become pregnant, children under 10 years of age, or patients taking certain other medications. Patients with liver or kidney issues or alcohol dependence should be especially cautious while taking this medication, and regular check-ups should be performed to monitor their condition. While this medication is generally safe, rare side effects such as liver function abnormalities, allergic reactions, dyspepsia, headaches, muscle pain, and skin rashes may occur; immediate notification to a physician is required if any abnormal symptoms arise. Pregnant or breastfeeding women should not take this medication, and women of childbearing age should use appropriate contraception while taking this medication. This medication may interact with various other medications; thus, inform the doctor or pharmacist if other medications are being taken, especially if taking specific antibiotics, antiviral agents, antifungals, blood pressure medications, or oral contraceptives. There is no specific antidote for overdose, so treatment should be symptomatic, and careful monitoring of liver function and muscle status should be conducted. This medication should be kept out of the reach of children and should not be stored in a different container from its original packaging. Elderly patients are at a higher risk of muscle-related side effects, so they require close monitoring while taking this medication. Furthermore, if symptoms such as muscle pain, muscle weakness, fatigue, or fever occur during treatment, medical assistance should be sought immediately, and if symptoms are severe or CK levels are elevated, the medication should be discontinued.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, skin peeling, pain in oral/eye mucosa, severe skin reactions, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities with cough and fever, yellowing of the skin or eyes (jaundice), extreme fatigue systemically, liver issues (jaundice), sudden and severe headache, lightning-like headache, swelling of the feet

Mild side effects

• Weakness
• lethargy
• chest pain
• peripheral edema
• fatigue
• fever
• rhinitis
• hyperglycemia
• hypoglycemia
• weight gain

This medication is sensitive to air and moisture; therefore, it should be stored in a tightly sealed container. It is recommended to maintain the storage temperature between 1°C and 30°C at room temperature.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle