Orotenion Tablet 5/20 mg (Amlodipine Besilate, Olmesartan Medoxomil)

Adult dose

This medication is administered once daily with water, irrespective of meals. It is recommended to take it at the same time each day (e.g., morning). The recommended doses are 5/20 mg, 10/20 mg, 5/40 mg, and 10/40 mg. Dosage adjustments should be made at intervals of more than 2 weeks based on the blood pressure response of the patient. For patients with renal impairment, liver impairment, or elderly patients, caution is required when adjusting the dosage.

Child dose

Safety and efficacy for pediatric patients under 18 years have not been established.

This medication can cause serious harm to the fetus, especially during the 2nd and 3rd trimesters of pregnancy, so it must be discontinued immediately upon confirmation of pregnancy. Those allergic to this medication or similar drugs, individuals who are pregnant or breastfeeding, people with severe liver or heart diseases, patients undergoing renal dialysis, those in shock, and patients with certain types of diabetes should not take this medication. Hypertensive patients who are deficient in fluids or sodium may experience excessively low blood pressure at the start of treatment, so they must be monitored carefully, and appropriate measures should be taken immediately if symptoms appear. Because rapid vasodilation can lead to hypotension, individuals with problems related to the heart or blood vessels should be particularly cautious. Patients with impaired kidney function may experience changes in renal function while taking this medication, so regular examinations are necessary. Patients with decreased liver function may experience delayed metabolism of this medication, so caution is advised during administration. Various side effects such as dizziness, headache, nausea, and edema can occur while taking this medication, and if symptoms worsen, consultation with a healthcare professional is recommended. Elderly patients may be more sensitive to this medication, so dosage adjustments and close monitoring of their condition are necessary. When taking this medication with other drugs, interactions may occur, so all medications currently being taken must be reported to the healthcare professional. Taking this medication during pregnancy may cause renal damage or other serious problems in the fetus, so individuals who are planning to become pregnant or who are pregnant must consult a doctor. In breastfeeding women, this medication may pass into breast milk and affect the baby, so it is recommended to discontinue breastfeeding or to stop taking this medication. Safety and efficacy for children under 18 years have not been established, therefore its use is not recommended. Overdosing on this medication can lead to severe hypotension and cardiac issues, so dosage should be adhered to strictly, and immediate medical attention should be sought in case of overdose. This medication should be kept out of reach of children and stored in a cool, dry place away from direct sunlight and moisture.

Serious side effects

• Hives
• angioedema
• hair loss
• pruritus
• acute renal failure
• intestinal vascular edema
• autoimmune hepatitis
• rhabdomyolysis
• hyperkalemia
• cholelithiasis

Mild side effects

• Dizziness
• headache
• decreased libido
• drowsiness
• sensory disturbances
• somnolence
• syncope
• vertigo
• palpitations
• rapid heartbeat

This medication must be stored in a tightly sealed container to prevent exposure to air or moisture, and should be kept at room temperature between 1 and 30 degrees Celsius. This way, the effectiveness of the medication can be well maintained.

Appearance

White round film-coated tablet

Package unit

28 tablets (14 tablets/PTP × 2)