Janutine Duo Tablet 50/850 mg

Adult dose

This medication is generally taken twice daily with food, and the dosage is gradually increased to reduce gastrointestinal adverse effects caused by metformin. 1. For patients not previously treated with metformin: The initial dose is one tablet of 50/500 mg taken twice a day, with possible dosage escalation to one tablet of 50/1000 mg twice a day. 2. For patients currently receiving metformin: The initial dosage is as per the sitagliptin component.

This medication is a combination product containing sitagliptin and metformin. Severe allergic reactions may occur while taking this medication; if skin rashes, breathing difficulties, or swelling of the face or neck occur, discontinue use immediately and consult a doctor. Additionally, severe adverse effects such as pancreatitis can occur, so if sudden abdominal pain, nausea, vomiting, or fever arise, seek medical attention immediately. This medication should not be administered to patients with severe renal impairment, dehydration, serious infections, or heart failure, and should be temporarily discontinued during radiological contrast examinations. It is not recommended for use in pregnant women or nursing mothers as safety has not been established. During treatment, be aware of signs of hypoglycemia, especially when used in conjunction with other hypoglycemic agents like insulin or sulfonylureas, as the risk of hypoglycemia may increase. Due to the metformin component, lactic acidosis, a rare but serious metabolic disorder, may occur; if sudden fatigue, muscle pain, breathing difficulties, or abdominal pain arise, seek immediate medical attention. Regular renal function and blood tests should be conducted while taking this medication, and monitoring for vitamin B12 deficiency is also necessary. Alcohol can increase the risk of side effects, so excessive drinking should be avoided while on this medication. If surgery is planned, the medication should be stopped 48 hours prior to the procedure and resumed only after normal renal function is confirmed post-surgery. Safety and efficacy have not been sufficiently established for children, and elderly patients should have dosage adjustments and careful monitoring due to risks of decreased renal function. Finally, if sudden joint pain or blisters on the skin occur during treatment, inform a doctor immediately and seek treatment.

Serious side effects

Urticaria, angioedema, chest tightness, difficulty breathing, anaphylaxis, Stevens-Johnson syndrome, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, dyspnea, asthma attack, jaundice, liver abnormalities, sudden and severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, significant decrease in urine output, generalized severe edema, increased blood pressure, acute pancreatitis, acute kidney failure, rhabdomyolysis.

Mild side effects

Diarrhea, upper respiratory infection, headache, nausea, vomiting, abdominal pain, nasopharyngitis, constipation, weakness, pruritus, thrombocytopenia, myalgia, limb pain, back pain, interstitial lung disease, peripheral edema, decreased appetite, itching, dizziness, weight loss, decreased serum vitamin B12, hypoglycemia, arthralgia accompanied by severity and dysfunction, blistering dermatitis.

This medication should be stored in a sealed container that is air-tight, ideally at room temperature between 1 to 30 degrees. Proper storage will help maintain the medication's effectiveness and prevent degradation.

Appearance

Pink oval film-coated tablet

Package unit

In-house packaging unit