Clopidogrel Tablets (Clopidogrel Bisulfate)

Adult dosage

For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease: Take 75 mg orally once daily. For patients with acute coronary syndrome: Start with a loading dose of 300 mg orally once daily on the first day, and thereafter take a maintenance dose of 75 mg orally once daily. In this case, aspirin 75 to 325 mg should be co-administered orally once daily. For patients with atrial fibrillation: Take 75 mg orally once daily, and aspirin 75 to 100 mg should be co-administered orally once daily.

This medication prevents platelets from aggregating, thus preventing blood from clotting. People with genetically decreased functionality of a specific enzyme (CYP2C19) may experience a reduced effect of this medication, which can increase the risk of heart attack or stroke; therefore, in such cases, treatment methods should be adjusted in consultation with a doctor. Taking this medication with drugs that activate enzymes can increase the concentration of this medication, raising the risk of bleeding, so it is advisable not to take them together. Patients who have an allergy to this medication or its components, those with bleeding disorders, severe liver damage, nursing women, or those with lactose intolerance should not take this medication. Patients at high risk of bleeding or those suspected of having bleeding symptoms should immediately undergo blood tests, and for those scheduled for surgery, it is recommended to discontinue this medication 5-7 days prior and restart only after hemostasis. Caution is required when taking this medication with other bleeding risk medications, anticoagulants, or certain antidepressants, as the risk of bleeding may increase. This medication may cause side effects related to bleeding such as gastrointestinal bleeding, bruising, nosebleeds, hematuria, thus should consult a doctor immediately if any abnormal symptoms occur. Pregnant women are advised to discontinue this medication 5-7 days prior to delivery due to an increased risk of bleeding during childbirth. In nursing mothers, as this medication may be excreted in breast milk, careful consideration should be given on whether to discontinue nursing or the medication. Elderly patients or those with impaired kidney or liver function may have an increased risk of bleeding, hence dosage adjustments and condition monitoring are necessary. In overdose situations, the risk of bleeding increases, and since there is no specific antidote, measures such as platelet transfusion may be necessary in case of significant bleeding. To ensure safety for children, this medication should be stored out of reach of children, and transferring it to another container may alter its quality, so caution is advised.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with high fever, blisters, peeling skin, oral/ocular mucosal pain, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough and fever, yellowing of the skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urination

Mild side effects

• Chest pain
• accidental injury
• influenza-like illness
• pain
• fatigue
• edema
• hypertension
• headache
• dizziness
• abdominal pain

This medication should be stored in a sealed container to prevent exposure to air, ideally at room temperature between 1 degree and 30 degrees. By storing it this way, the effectiveness of the medication is maintained for safe use.

Appearance

Pink round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle