Fineblue Injection

Adult administration

Use according to physician’s prescription while checking the plasma levels of trace elements for dosage adjustment. - Permissible dosage range (for intravenous use) - Zinc 2.5～4mg per day Copper 0.5～1.5mg per day Manganese 0.15～0.8mg per day Chromium 10～15μg per day Patients receiving parenteral nutrition Acute catabolic patients 4.5～6mg per day Patients with fluid losses from the intestines should additionally receive 12.2mg/L (amount of intestinal fluid loss).

Child administration

Pediatric patients - Under 5 years: 100μg per day per kg of body weight - Infants weighing less than 3kg: 300μg per day per kg of body weight 20μg per day per kg of body weight 2～10μg per day per kg of body weight per day per kg

This medication should be diluted before use; if administered undiluted through intravenous injection, it may cause inflammation in blood vessels. This medication should only be used when mixed with other drugs for injection as it is a low osmotic pressure solution. If any component of this medication causes toxic effects, administration must be stopped immediately. The zinc, copper, manganese, and chromium contained in this medication are in very small amounts, so toxic symptoms are not generally observed within the prescribed dosage. Before injection, physicians should carefully assess the patient's health status and the amount of nutrients the body requires. Zinc is primarily eliminated through the kidneys, so caution is needed for patients with impaired kidney function as zinc may accumulate in the body. Copper and manganese are mainly excreted through bile; therefore, patients with biliary problems may be at risk of accumulation of these components. Manganese is also eliminated through pancreatic juice and may be partially reabsorbed in the intestines, which can affect manganese concentration in the body. Chromium may affect blood glucose control, so diabetic patients must confirm their use of diabetes medications before taking this medicine. Women who are pregnant or may become pregnant should use this medication only when the benefits of treatment outweigh potential risks, as its safety has not been fully established. Excessive intake of zinc can cause serious symptoms, including nausea, vomiting, dehydration, dizziness, abdominal pain, drowsiness, loss of coordination, weakness, behavioral abnormalities, diarrhea, progressive wasting syndrome, muscle tone reduction, glare, peripheral edema, nausea, vomiting, ulcers, kidney disorders, liver disorders, seizures, and coma. Excessive intake of copper can result in symptoms such as fatigue, behavioral abnormalities, diarrhea, decreased muscle tone, glare, and swelling; D-penicillamine can be used as an antidote. Toxicity from excessive manganese intake has been reported infrequently in patients receiving parenteral nutrition, but no toxicity is known from normal food or beverage consumption. Excessive chromium intake may cause nausea, vomiting, ulcers, renal and hepatic dysfunction, and in severe cases, seizures and coma; caution is advised. This medication must be used strictly according to a physician’s prescription and should not be used arbitrarily without a prescription. When adding this medication to parenteral nutritional solutions, it is recommended to work in a laminar flow environment to maintain a sterile condition for infection prevention.

Serious side effects

• Peripheral edema
• liver disorders
• seizures
• coma

Mild side effects

• Nausea
• vomiting
• dehydration
• electrolyte imbalance
• dizziness
• abdominal pain
• drowsiness
• coordination disorders
• weakness
• behavioral abnormalities

This medication should be stored in a sealed container to prevent air and moisture ingress, and it is safe to store at room temperature between 1 to 30 degrees Celsius. Storing it this way helps maintain the drug's efficacy and prevents degradation.

Appearance

A light blue transparent liquid contained in a colorless and transparent vial for injection

Package unit

2mL/vial x 10 vials