Atorvan Tablets 20mg (Atorvastatin Calcium Trihydrate)

Adult dosage

For hyperlipidemia, the recommended initial dosage is 10 mg of atorvastatin once daily. For patients requiring greater reduction of LDL cholesterol levels, treatment may start with 20 mg or 40 mg once daily. The dosage can be adjusted within the range of 10 to 80 mg once daily. Lipid levels should be analyzed within 2 to 4 weeks after starting treatment and dosage adjustments should be made accordingly. In the case of homozygous familial hypercholesterolemia, the dosing regimen is 10 to 80 mg once daily, either in conjunction with other lipid-lowering therapies (e.g., LDL apheresis) or when such therapies are not possible. For pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17), the recommended initial dosage is 10 mg once daily, with a maximum recommended dosage of 20 mg once daily (there is no clinical data on doses higher than 20 mg in this pediatric population). The dosage should be adjusted according to the individual patient’s relevant treatment goals, with modifications being made at intervals of 4 weeks or more. ○ In patients with renal impairment: Renal disease does not affect atorvastatin plasma concentrations or LDL cholesterol-lowering effects, thus dosage adjustment is not required. ○ In the elderly: The efficacy and safety in patients aged 70 and older are similar to those in the general adult population.

Children's dosage

For pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17), the recommended initial dosage is 10 mg once daily, with a maximum dosage of 20 mg once daily. The dosage should be adjusted based on treatment goals and may be modified every 4 weeks.

This medication should be discontinued immediately if any unusual muscle symptoms occur. If symptoms such as muscle pain, weakness, or cramps worsen, a physician should be consulted. This medication should not be used in patients with impaired liver function or a history of liver disease. Regular liver function tests should be conducted if liver dysfunction is suspected. Women who are pregnant, may become pregnant, or are breastfeeding should not take this medication. Women of childbearing potential should use appropriate contraceptive methods while on this medication. This medication is not prescribed to children under 10 or to patients with certain genetic lactose intolerances. Special caution should be taken when administering this medication to alcoholics, patients with decreased kidney function, and elderly patients, who should be closely monitored for muscle-related side effects. This medication may interact with other drugs; therefore, if you are taking any other medications, you must inform your doctor or pharmacist. Caution is particularly needed when taken with certain antibiotics, antifungals, antivirals, antihypertensives, or antidiabetic agents. In the event of an overdose, there is no specific antidote, so appropriate treatment should be administered based on symptoms, with monitoring of liver function and muscle status. This medication should be kept out of the reach of children and stored in its original container for safety. If you experience symptoms such as muscle pain, fatigue, or fever during treatment, it is important to notify healthcare professionals immediately and undergo examination.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe allergic reactions, severe rash with high fever, blisters, skin sloughing, pain in oral/ocular mucosa, severe skin reactions, asthma attacks, respiratory difficulties with cough and fever, yellowing of skin or eyes (jaundice), severe lethargy, liver dysfunction (jaundice), sudden and severe headache, thunderclap headache, seizures, loss of consciousness.

Mild side effects

• Weakness
• fatigue
• chest pain
• peripheral edema
• fever
• rhinopharyngitis
• hyperglycemia
• hypoglycemia
• weight gain
• loss of appetite

This medication may be sensitive to air or moisture; therefore, it should be stored in a tightly sealed container. It is advisable to maintain a storage temperature between 1 to 30 degrees Celsius at room temperature.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle