Cirex Capsule (Celecoxib)

Adult dose

The minimum recommended dose of this medicine should be adjusted according to the patient and may be administered regardless of meals. ○ Adults 1. Osteoarthritis (degenerative arthritis) Take 200 mg of celecoxib once daily, or divide the dose into 100 mg per dose twice daily. 2. Rheumatoid arthritis Take 100 mg or 200 mg of celecoxib per dose twice daily. 3. Ankylosing spondylitis (AS) Administer 200 mg of celecoxib once daily, or divide the dose into 100 mg per dose twice daily. If no effect is observed after 6 weeks, a dose of up to 400 mg per day may be administered. If no effect is observed after 6 weeks of treatment with 400 mg per day, other treatment options should be considered. 4. Acute pain and primary dysmenorrhea The recommended initial dose is 400 mg of celecoxib, with an additional 200 mg on the first day of treatment if needed. From the second day of treatment, the recommended dose is 200 mg per dose twice daily, if needed. ○ Patients with hepatic impairment For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication should only be taken after consulting with a doctor or pharmacist if the person regularly consumes more than three alcoholic drinks a day, as there is a risk of gastrointestinal bleeding. This drug may increase the risk of cardiovascular thromboembolic events, myocardial infarction, and stroke, and should only be used at the lowest effective dose and for the shortest duration necessary; if any cardiovascular symptoms occur, medical consultation should be sought immediately. Serious adverse reactions such as perforation, ulceration, and bleeding in the gastrointestinal tract may occur, particularly in elderly patients or those with a history of gastrointestinal disease. This drug should not be prescribed to individuals with certain allergic histories, severe liver or kidney impairment, active gastrointestinal bleeding, heart failure, or pregnant women. Patients with impaired liver or kidney function, asthma, hypertension, and elderly patients should use this medication cautiously and require regular monitoring. During the course of taking this medication, adverse reactions such as headache, dizziness, indigestion, vomiting, skin rash, edema, hypertension, anxiety, drowsiness, influenza-like symptoms, facial flushing, fatigue, malaise, tinnitus, unstable angina, arrhythmias, palpitations, constipation, dental diseases, stomatitis, urinary disturbances (dysuria, frequency, hematuria), kidney function impairment, elevated liver enzymes, liver function abnormalities, alopecia, gastric ulcers, and esophagitis may occur; if symptoms are severe, consult medical personnel immediately. Particularly, if skin rashes, blisters, or mucosal lesions occur, it may indicate a serious skin reaction, and the medication should be stopped immediately, and healthcare personnel should be consulted. This drug may interact with other medications; therefore, it is essential to inform the healthcare provider of any other medications being taken, and regular checks of blood pressure, kidney function, and liver function should be performed. Women who are pregnant or may become pregnant, as well as nursing mothers, should not take this medication, and women planning a pregnancy should consult a healthcare provider before taking this medication. Elderly patients may be at increased risk for declining kidney and liver function, so careful observation and dosage adjustments are necessary when taking this medication. Dizziness or drowsiness may occur while using this medication, so caution is advised when driving or operating machinery. Long-term use of this medication requires regular blood tests and assessments of liver and kidney function, and immediate consultation with medical personnel is required if any abnormalities arise.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforations of the upper and lower gastrointestinal tract, ulcers, bleeding, bronchitis, sinusitis, upper respiratory tract infections, urinary tract infections, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusion, dizziness, muscle rigidity, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, dyspepsia, abdominal distension, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevated liver enzymes, itching, rash, hives, petechiae, angioedema, alopecia, blistering dermatitis, peripheral edema, facial edema, influenza-like illness, damage, taste disturbance, albuminuria, cystitis, hematuria, dysuria, urinary frequency, kidney stones, urinary incontinence, urinary tract infection, visual disturbances, cataract, conjunctivitis, ocular pain, glaucoma, ocular bleeding, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urine hematuria, positive urine protein, renal impairment, acute renal failure, interstitial nephritis, headache, migraine, neuralgia, neuropathy, paresthesia, cerebral infarction, aseptic meningitis, ataxia, suicide, hyposmia, ageusia, back pain, exacerbation of allergies, allergic reactions, weakness, chest pain, fluid retention, systemic edema, facial edema, fatigue, lethargy, fever, facial flushing, influenza syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reaction, angioedema, loss of appetite, increased appetite, depression, neurological hyperreactivity, drowsiness, fatal intracranial bleeding, hallucinations, worsening of epilepsy, upper respiratory infection, shingles, wound infection, gingivitis, herpes simplex, herpes zoster, bacterial infection, fungal infection, soft tissue infection, viral infection, candidiasis, genital candidiasis, otitis media, breast tenderness, menopausal symptoms, fibrocystic breast disease, thoracic neoplasm, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostatic disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment, liver dysfunction, elevated ALT, elevated AST, increased γ-GTP, elevated ALP, positive urobilinogen, cholelithiasis, hepatitis, jaundice, liver failure, fulminant hepatitis, hepatic necrosis, increased serum sodium, increased serum potassium, elevated BUN, increased CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, elevated creatinine, increased alkaline phosphatase, weight gain, elevated LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthropathy, skeletal abnormalities, myalgia, cervical dystonia, synovitis, tendinitis, myositis, leg cramps, fractures, tendon ruptures, pain in various parts of the body, muscle rigidity, decreased hematocrit, increased hemoglobin, petechiae, nosebleeds, thrombocytopathy, anemia, thrombocytopenia, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, granulomatous inflammation, contact dermatitis, injection site reactions, cutaneous nodules, visual disturbances, cataract, conjunctivitis, ocular pain, glaucoma, ocular bleeding, retinal artery or vein occlusion, acute renal failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, focal segmental glomerulosclerosis, menstrual disorders, female infertility, chest pain, anaphylactic reaction, hallucinations, cerebral hemorrhage, vasculitis, pulmonary embolism, interstitial pneumonia, gastrointestinal bleeding, hepatitis, photosensitivity reaction, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash associated with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, exfoliative dermatitis

This medication should be stored in a tightly sealed container to prevent exposure to air, and it is best kept at room temperature between 15 and 30 degrees Celsius. Doing so will help maintain the medication's effectiveness and safety.

Appearance

A capsule of white to light yellow powder filled in a white capsule.

Package unit

30 capsules/bottle, 100 capsules/bottle