Sitagliptin/Metformin XR Sustained Release Tablet 100/1000 mg

Adult dose

This sustained release tablet of 100/1000 mg should be taken once daily, one tablet per dose. Patients taking the 50/500 mg sustained release tablet or the 50/1000 mg sustained release tablet should take two tablets simultaneously once daily. 1. For patients not currently receiving metformin treatment: The initial dose should be 100 mg of sitagliptin and 1000 mg of metformin per day. If the initial dose is not sufficient for blood sugar control...

This medication contains sitagliptin and metformin, and is used for diabetes treatment. Though rare, it may cause serious allergic reactions; if symptoms such as hives, rash, difficulty breathing, or swelling of the face or neck occur, usage should be stopped immediately and a healthcare professional consulted. Acute pancreatitis may occur, so if symptoms such as severe abdominal pain, vomiting, or fever arise, the doctor should be notified immediately. This medication should not be administered to patients with severely decreased kidney function, heart failure, severe infections, or dehydration, and should be temporarily discontinued before and after examinations using radiocontrast agents. It is not to be administered to women who are pregnant or may become pregnant, nursing mothers, or children and adolescents under 18 years of age. As this medication is excreted through the kidneys, elderly patients or those with reduced kidney function should undergo regular kidney function tests, and dosage adjustments may be necessary. Be cautious of hypoglycemic symptoms during treatment, especially when taken together with insulin or sulfonylurea medications as the risk of hypoglycemia may increase. Due to the metformin component, lactic acidosis, a rare but potentially fatal metabolic disorder, may occur, so if severe dehydration, liver disease, cardiopulmonary disease, or excessive alcohol consumption is present, usage should be stopped immediately and medical consultation should follow. During the course of treatment, regular meals and exercise should be maintained, and regular blood sugar, kidney function, and blood tests should be conducted to monitor treatment effectiveness and side effects. Additionally, inform healthcare professionals if any other medications that may interact with this drug are being taken. In the case of surgery or severe trauma, this medication should be temporarily discontinued, and resumed only after the patient's condition stabilizes. Finally, if there are any occurrences of blisters or severe joint pain while taking this medication, consult a doctor immediately.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, cold sweat, pallor, anaphylaxis, severe rash accompanied by high fever, blisters, skin peeling, mucosal pain in the mouth/eyes, Stevens-Johnson syndrome, acute pancreatitis, difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of the skin), extreme lethargy, sudden and severe headache, thunderclap headache, seizure, altered consciousness, blurred vision

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• rhinitis
• constipation
• muscle pain
• limb pain

This medication is sensitive to air and moisture; therefore, it should be stored in a tightly sealed container. Also, avoid storing in extremely hot or cold places, and it is recommended to keep it at room temperature between 1 and 30 degrees Celsius.

Appearance

Bright blue, bilaterally convex, oval-shaped, sustained release film-coated tablet

Package unit

30 tablets/bottle