Kranos 5 mg Tablet (Amlodipine Besylate)

Adult dose

Administer 5 mg orally once daily as amlodipine, and may increase to a maximum of 10 mg daily according to the patient's response. Adjust appropriately based on age and symptoms.

This medication should not be used in certain patients. Patients who have had allergies to this medication or similar drugs, nursing women, patients with severe liver dysfunction, patients with severe aortic stenosis, and patients in shock should not take this medication. Additionally, there are cases where caution is advised. Patients with severe hypotension, patients with renal failure requiring dialysis, the elderly, and pregnant or potentially pregnant women should be particularly careful when taking this medication. This medication is generally well tolerated; however, side effects such as flushing, fatigue, swelling, palpitations, dizziness, headache, drowsiness, abdominal pain, and nausea may commonly occur. Rarely, various adverse reactions have been reported, including weakness, blood pressure decrease, sensory abnormalities, erectile dysfunction, vomiting, hyperglycemia, myalgia, reduced blood cell counts, insomnia, cough, and skin rash. Caution should be exercised in heart failure patients, as this medication can worsen pulmonary edema, and in patients with impaired liver function, the drug's half-life may be prolonged, necessitating dose adjustment and monitoring. This medication lowers blood pressure slowly; therefore, it is not suitable for treating acute unstable angina. It is known to have little impact on the ability to drive or operate machinery. This medication can interact with various other drugs; therefore, patients taking other medications should consult their healthcare professionals. In particular, taking this medication with grapefruit juice may enhance the drug's effect and should be avoided. Pregnant or nursing women should use this medication only when absolutely necessary and under the guidance of a physician, and it is recommended to discontinue breastfeeding. In children, it can be used from the age of 6, and should be used within confirmed effective and safe dosages. In case of overdose, severe hypotension and cardiac issues may occur, and immediate medical assistance should be sought; emergency interventions such as gastric lavage or drug administration may be required.

Serious side effects

• Urticaria
• severe swelling (edema)
• jaundice
• toxic epidermal necrolysis.

Mild side effects

• Flushing
• fatigue
• swelling
• palpitations
• dizziness
• headache
• drowsiness
• abdominal pain
• nausea
• weakness

This medication may be sensitive to air and moisture; therefore, it should be stored in a sealed container. The recommended storage temperature is between 1 to 30 degrees Celsius at room temperature.

Appearance

White octagonal tablet

Package unit

30 tablets/bottle, 300 tablets/bottle