Adapin OSMO Sustained Release Tablets 30 mg (Nifedipine)

Adult dosage

Initially, administer 30mg or 60mg once daily, usually for 7-14 days, adjusting the dose according to the patient's condition. Hypertension: A starting dose of 20mg or 30mg is recommended. Because the drug concentration in the blood reaches steady state from the second day, the titration period may be shortened by frequently assessing the patient's condition. Do not exceed a maximum dose of 120mg. The dose must be adjusted according to the patient's symptoms. Because this drug uses an osmotic drug-release mechanism (OROS formulation), it may be administered regardless of meals (there is no difference in absorption when taken on an empty stomach or after a meal). When administering to older adults, start with a low dose and administer cautiously according to the patient's response. The maintenance dose may be lower than that for younger patients. Patients with hepatic impairment should be monitored carefully, and dose reduction may be necessary. Dose adjustment is not required in patients with renal impairment; however, administer cautiously in severe cases.

Children's dosage

Use of this drug is not recommended in children under 18 years of age because its safety and efficacy have not been established.

This medication should not be administered to certain patients. For example, individuals with allergies to this medication, pregnant or lactating women, those with severe heart problems or low blood pressure, and patients who have had certain surgeries may be at risk when taking this medication. Furthermore, patients with severe liver or kidney dysfunction, heart failure, the elderly, and diabetic patients should be particularly cautious when using this medication and may require dose adjustments. While taking this medication, various side effects may occur, such as changes in liver function, abnormal urination, blood abnormalities, heart-related symptoms, neurological symptoms, gastrointestinal issues, and skin reactions, so immediate consultation with a doctor is necessary if unusual symptoms arise. This medication should be tapered off slowly according to the doctor's instructions to avoid worsening of symptoms, and care should be taken as dizziness may occur while driving or operating dangerous machinery. If chest pain occurs within 30 minutes after starting or increasing the dose, use should be discontinued immediately. Pregnant and lactating women should avoid taking this medication, and women who may become pregnant should also refrain from use. This medication is not recommended for children under 18 years of age as its safety and efficacy have not been established. Elderly patients should start at a lower dose and be monitored closely, with adjustments made as necessary. In cases of overdose, symptoms such as altered consciousness, low blood pressure, irregular heart rhythms, and metabolic abnormalities may occur, requiring immediate emergency treatment. This medication should not be taken with grapefruit juice, as it can increase blood concentration and elevate the risk of side effects. Additionally, this medication should not be chewed or crushed but taken whole with a small amount of water, and patients with a history of gastrointestinal obstruction should take caution. This medication has many drug interactions, and dose adjustments or monitoring may be necessary depending on the concomitant medications, so patients must inform their physician or pharmacist.

• Jaundice
• elevated AST
• elevated ALT
• elevated ALP
• elevated BUN
• elevated creatinine
• nocturia
• polyuria
• dysuria
• frequent urination

This medication should be stored in a sealed container that blocks light and kept at room temperature between 1 to 30 degrees Celsius. Storing it this way preserves the medication's efficacy well.

Appearance

Pink round film-coated tablets

Package unit

100 tablets/box [10 tablets/PTP × 10]