Bovis Tablet

Adult dose

Typically administered orally, 2 tablets twice daily in the morning and before bed, regardless of meals. 1) Gastric and duodenal ulcers: Administer 2 tablets twice daily or 4 tablets once daily before bed. Specifically for duodenal ulcer patients, taking 4 tablets twice daily in the morning and at bedtime can achieve a higher treatment rate. The dosage is the same for the prevention of ulcers caused by NSAIDs or for long-term use of NSAIDs, where gastric and duodenal ulcers may occur. Generally, diseases caused by NSAIDs are expected to heal within 8 weeks, though the healing time may occasionally extend depending on the patient. For recurrent ulcer patients who had excellent effects during short-term therapy, 2 tablets should be administered once daily before bed as maintenance therapy. 2) Gastroesophageal reflux disease: Administer 2 tablets twice daily for 8 weeks or 4 tablets once daily at bedtime. In cases of severe gastroesophageal reflux disease, the dosage may be increased to 4 tablets four times daily. 3) Zollinger-Ellison syndrome: Treatment begins at an initial dose of 2 tablets three times daily, which can be increased as needed. In cases of severe illness, a physician may instruct a total daily dose of up to 6 g of ranitidine. 4) Peptic ulcers, acute stress ulcers, and upper gastrointestinal bleeding due to acute mucosal lesions: Once oral administration is possible, it should be switched from injection to oral administration at a dose of 2 tablets twice daily. 5) Pre-anesthesia administration (prevention of Mendelson syndrome): Administer 2 tablets 2 hours prior to induction of anesthesia. In this case, it is also advisable to administer 2 tablets the night before surgery.

This drug should not be used in patients with impaired renal function or those on dialysis. Patients who have had an allergic reaction to this drug or its components should also avoid taking it. It is not administered to patients with a history of acute porphyria, as this medication may exacerbate their symptoms. It is also advisable to avoid use in patients who have undergone upper gastrointestinal surgery, pregnant women, women who may become pregnant, and premature or newborn infants. Patients undergoing dietary restrictions on potassium intake should not take this medicine. Caution is advised when using this drug in patients with impaired liver function, previous drug allergies, the elderly, and those with kidney issues. Patients taking NSAIDs together with this medication, especially elderly patients or those with a history of peptic ulcers, require regular medical check-ups. This drug may mask symptoms of stomach cancer, so patients with gastric ulcers or those over middle age who have recently developed or changed dyspeptic symptoms should confirm malignancy before treatment. Patients with gastric and duodenal ulcers infected with Helicobacter pylori should also receive treatments to eliminate the bacteria. Severely ill patients in intensive care units should be monitored for the risk of gastric stones. The aluminum components in this drug can bind to phosphates, hindering phosphate absorption; hence, patients with hypophosphatemia should be cautious. Patients who have difficulty swallowing may experience respiratory complications after taking this medication, so they should exercise caution. There may be rare cases of severe allergic reactions such as anaphylactic shock during the use of this drug; if symptoms occur, discontinue use immediately and consult medical personnel. Hypersensitivity reactions such as skin rash, urticaria, angioedema, fever, and bronchospasm may also occur, and dosing should be stopped if these symptoms develop. Abnormal results may appear in blood tests, so if systemic weakness, bleeding, fever, or similar symptoms occur, immediate testing is warranted. Symptoms of liver dysfunction may also present; if jaundice or hepatitis symptoms appear, discontinue use. Cardiovascular issues such as arrhythmia or vasculitis have been reported rarely. Gastrointestinal symptoms may include nausea, vomiting, constipation, diarrhea, and abdominal distension. Central nervous system symptoms may include dizziness, drowsiness, confusion, convulsions, insomnia, and headache; attention is necessary if unusual symptoms are present. Hormonal-related symptoms such as gynecomastia, excessive milk secretion, erectile dysfunction, and decreased libido have been reported, though causality is unclear. Myalgia, arthralgia, and in severe cases, rhabdomyolysis may occur; if muscle abnormalities are felt, medical advice should be sought promptly. Skin rash or hair loss symptoms have also been reported rarely, so changes in the skin should be monitored closely. It is recommended not to take this drug for long periods, and routine blood tests, including liver and kidney function tests, should be performed regularly during treatment. Elderly patients, those with chronic lung diseases, and diabetics are at an increased risk of pneumonia and should be cautious. If dizziness or drowsiness occurs after taking this medication, driving or operating hazardous machinery should be avoided. This drug may interact with other medications; thus, if the patient is taking anticoagulants or certain antibiotics and anticonvulsants, they should inform their physician or pharmacist. It is safer not to take this drug during pregnancy or while breastfeeding. Safety for pediatric use has not been established; therefore, it is advisable to avoid use in children. In cases of overdose, emergency measures such as vomiting or gastric lavage may be necessary; thus, immediate hospital visitation is required. This drug may reduce gastric acid secretion and promote bacterial overgrowth in the stomach; hence long-term use requires regular medical examinations, including ophthalmologic evaluations.

Serious side effects

Urticaria, angioedema, shock (anaphylactic shock), chest pain, bronchospasm, hypotension, skin rash, vascular swelling, chest tightness, difficulty breathing, severe swelling (edema), liver dysfunction (jaundice), severe skin adverse reactions (severe rash, blisters, skin peeling), severe allergic reaction, severe edema, urinary abnormalities, consciousness disorders, convulsions, vision abnormalities, paralysis, severe neurological symptoms, severe headaches, seizures, lightning

Mild side effects

• Skin rash
• urticaria
• angioedema
• fever
• bronchospasm
• hypotension
• chest pain
• nausea
• vomiting
• constipation

This medication should be stored in a tightly closed container to keep air and moisture out. The storage temperature should be maintained at room temperature between 1 to 30 degrees Celsius.

Appearance

This medication is a round white film-coated tablet.

Package unit

30 tablets/bottle, 300 tablets/bottle