Cranos Tablets 10mg (Amlodipine Besylate)

Adult dose

Adults: Administer Amlodipine at 5mg orally once daily, and may increase to a maximum of 10mg daily depending on patient response. Adjust appropriately based on age and symptoms.

This medication should not be used in certain patients. For example, it is contraindicated in individuals allergic to this or similar medications, nursing women, patients with severe liver dysfunction, patients with severe aortic stenosis, and those in a shock state. Additionally, special caution should be taken when using this medication in patients with severe hypotension, patients requiring dialysis for renal failure, elderly patients, and women who are pregnant or may become pregnant. Various side effects may occur while taking this medication. The most common side effects include facial flushing, fatigue, swelling, palpitations, dizziness, headache, drowsiness, abdominal pain, and nausea. Rarely, various adverse reactions have been reported, including lethargy, weight change, hypotension, neurological symptoms, erectile dysfunction, digestive disturbances, changes in blood levels, insomnia, and skin rashes. Caution is needed when using this medication in patients with heart failure due to the potential for pulmonary edema; dosage adjustments are necessary in patients with liver impairment. The effects of this medication appear gradually, and it is not suitable for situations requiring rapid blood pressure reduction. This medication is generally unlikely to impair driving or machine operation capabilities. Interactions may occur when taken with other medications; therefore, especially when taken with specific antibiotics or antihypertensives, or grapefruit juice, consultation with healthcare professionals is advised. Its safety during pregnancy has not been established; thus, it is only to be used when absolutely necessary, and nursing should be discontinued while taking this medication. Pediatric patients can only use this medication if they are 6 years of age or older, as efficacy in children under 6 years has not been established. In cases of overdose, severe hypotension and cardiac issues may occur, necessitating a visit to a healthcare institution immediately, where blood pressure and heart status should be closely monitored and necessary supportive treatment administered.

Serious side effects

• Urticaria
• angioedema
• toxic epidermal necrolysis
• jaundice
• hepatitis
• severe edema
• non-cardiogenic pulmonary edema.

Mild side effects

• Flushing
• fatigue
• edema
• palpitations
• dizziness
• headache
• drowsiness
• abdominal pain
• nausea
• lethargy

This medication should be stored in a tightly closed container to protect it from air and moisture. Additionally, it is safe to store the medication at room temperature, between 1 to 30 degrees Celsius, avoiding extreme cold or heat.

Appearance

White round tablet

Package unit

30 tablets/bottle, 300 tablets/bottle